A sertoliform endometrioid adenocarcinoma of the endometrium

Fox, H.; Brander, W. L.

doi:10.1111/j.1365-2559.1988.tb02087.x

Cited by 16 publications

(11 citation statements)

References 3 publications

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“…[45] Subsequently, SEC arising from uterus has also been reported. [6] Similarity of SEC to sex cord tumor may result in misdiagnosis. Eight out of 13 cases of SEC were initially diagnosed with sex-cord tumors in the case series described by Young et al .…”

Section: Discussionmentioning

confidence: 99%

Sertoliform endometrioid carcinoma of ovary presenting as abdominal wall abscess

et al. 2018

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Sertoliform endometrioid carcinoma (SEC) is a rare epithelial ovarian cancer which may be mistaken for sex cord tumour on microscopy. Immunohistochemistry and extensive sampling of tumour to look for areas of conventional endometrioid carcinoma are important to confirm the diagnosis of SEC. We report a case of SEC of ovary in a postmenopausal lady who presented to us with abdominal wall abscess in epigastric region.

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Section: Discussionmentioning

confidence: 99%

Sertoliform endometrioid carcinoma of ovary presenting as abdominal wall abscess

et al. 2018

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“…SEC is a rare variant of endometrioid adenocarcinoma, most of which were reported in the ovary and rare cases in the endometrium (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). It causes important diagnostic difficulties for the pathologist due to its morphologic resemblance to sex cord stromal tumors, especially sertoli cell tumor and sertoli leydig cell tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Then Fox et al defined the first case of endometrium (3) and to date, nearly 80 cases of the ovary (1, 2, 4-9) and nearly 20 cases of the endometrium (3,10,(11)(12)(13)(14) were reported in the literature. Its morphologic similarity to sex cord stromal tumors such as sertoli cell tumor, sertoli-leydig cell tumor or rarely granulosa cell tumor causes diagnostic pitfall for the pathologist.…”

Section: Sertoliform Endometrioid Carcinomamentioning

confidence: 99%

Ovarian sertoliform endometrioid adenocarcinoma: A rare variant which causes diagnostic pitfalls

Kankaya¹,

Kahraman²,

Ortaç³

et al. 2015

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Sertoliform endometrioid carcinoma (SEC) is a rare variant of endometrioid adenocarcinoma, which causes diagnostic pitfalls due to its morphologic resemblance of sex cord stromal tumors. Herein, we report a case of SEC in the ovary almost all of which consisted of sex-cord like areas and was presumed to be a sertoli cell tumour initially. Immunohistochemical features incompatible with sertoli cell tumour were alerting and extensive sampling revealed a focal component of classical endometrioid carcinoma with anastomosing cribriform areas of more columnar cells. The final diagnosis was sertoliform endometrioid adenocarcinoma. This entity should be kept in mind for all the pathologists and gynaecologic oncologists. Sampling such tumours extensively and confirming the diagnosis by immunohistochemistry using a large antibody panel is requisite for the correct diagnosis and preventing the patient from inappropriate therapies.

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“…These tumors resemble well-differentiated Sertoli cell tumors and are associated with typical endometrioid carcinoma, which usually merges with the sertoliform areas (1)(2)(3)(4)(5)(6)(7). The immunophenotype of these neoplasms shows no evidence of genuine sex cord differentiation (3,4,(6)(7)(8).…”

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confidence: 99%

“…Endometrioid carcinomas resembling Sertoli cell tumors or so-called sertoliform carcinomas have been well documented in the ovary (1)(2)(3)(4), and subsequently also in the endometrium (5)(6)(7). These tumors resemble well-differentiated Sertoli cell tumors and are associated with typical endometrioid carcinoma, which usually merges with the sertoliform areas (1)(2)(3)(4)(5)(6)(7).…”

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confidence: 99%

Uterine Retiform Sertoli-Leydig Cell Tumor

Czernobilsky

Mamet

David

et al. 2005

International Journal of Gynecological Pathology

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We report a case of a retiform Sertoli-Leydig cell tumor of intermediate differentiation presenting as a uterine intracavity polypoid mass in a 63-year-old woman. In contrast to sertoliform endometrioid carcinoma and to hitherto reported uterine tumors resembling ovarian sex cord tumors (UTROSCTs), which are primarily characterized by tubular glands and solid tubules, this tumor, which most likely represents a UTROSCT, showed a large spectrum of histologic features typical of a genuine retiform Sertoli-Leydig cell tumor. The diagnosis was confirmed by a battery of immunohistochemical stains, which also served as a tool for differential diagnosis with other neoplasms. The tumor cells were positive for broad spectrum keratin (CK) CK18, vimentin, calretinin, and progesterone receptor. Only a few isolated cells stained for inhibin. The tumor cells were negative for CK7, CK5/6, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), thrombomodulin, 013 (CD99), melan A, alpha-fetoprotein (AFP), placental alkaline phosphatase (PLAP), alpha-1-antitrypsin, estrogen receptor, S100, neurone specific enolase (NSE), chromogranin, synaptophysin, desmin, caldesmon, and CD10. Divergent differentiation of uterine cells seems to be the most likely pathogenetic mechanism. To the best of our knowledge, no UTROSCT showing such a variety of histologic features indicative of a true sex cord tumor has been reported before.

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A sertoliform endometrioid adenocarcinoma of the endometrium

Cited by 16 publications

References 3 publications

Sertoliform endometrioid carcinoma of ovary presenting as abdominal wall abscess

Sertoliform endometrioid carcinoma of ovary presenting as abdominal wall abscess

Ovarian sertoliform endometrioid adenocarcinoma: A rare variant which causes diagnostic pitfalls

Uterine Retiform Sertoli-Leydig Cell Tumor

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