This study aimed to analyze the trends in library and information science (LIS) research in Tanzania from 1990 to 2023. A descriptive research design utilizing a content analysis approach was employed to analyze data sourced from Google Scholar during the specified period. The study identified an overall fluctuating trend in LIS research, with a shift in research focus from information-seeking to other areas within the LIS domain. The predominant methodologies observed in most LIS studies were descriptive research design and a mixed methods approach. The study further highlighted a dynamic pattern in research collaboration, albeit with limited international collaboration. Additionally, there was a noticeable underrepresentation of female researchers in the LIS field, as evidenced by the scarcity of publications authored solely by women. The University of Dar es Salaam, Sokoine University of Agriculture, and Mzumbe University emerged as the top three institutions contributing to LIS research. While most LIS researchers published their work in the University of Dar es Salaam Library journal, there was a growing tendency to also publish in other similar international journals. Overall, this study contributes to the existing literature on LIS research trends, emphasizing the evolving nature of LIS research in Tanzania. It also underscores the importance of Tanzanian LIS researchers to actively seek international collaborations to enhance the impact of their research and further advance the field on a global scale.