A severity score comprising patient age, ulcer chronicity, and venous refill time predicted venous leg ulcer healing at 24 weeks

Gibson, Jo

doi:10.1136/ebn.10.4.122

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…Group I received aspirin alone (200 mg/kg,p.o.). Group II received omeprazole orally at the dose of 20 mg/kg body [11], Group III, Group IV, and Group V received BNLE orally at the doses of 100,200 and 300 mg/kg body weight respectively. The pylorus was ligated, care being exercised that neither damage to the blood supply nor traction on the pylorus occurs.…”

Section: Antiulcer Activitymentioning

confidence: 99%

Antioxidant and Antiulcer Potential on leaves of Brassica nigra L. against Gastric Ulcer

Tripathi

Punekar²,

Jain

et al. 2017

ijpm

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<br /><table class="data" width="100%"><tbody><tr valign="top"><td class="value"><p>In the present study, anti-ulcerative effects of extract of Brassica nigra L. leaves were investigated in pylorus ligation and aspirin-induced gastric ulcer models in rats. In present study antiulcer effect of ethanolic extract of Brassica nigra leaves is well understood by total acidity, free acidity, and ulcer index of different groups of animals in both the model viz. Pylorus ligation model & Aspirin induced gastric ulcer in experimental rats when compared the test group with control and standard group. The percentage of ulcer inhibition was observed in pylorus ligated model was as follows: standard, BNLE 100mg/kg, BNLE 200mg/kg and BNLE 300mg/kg 55.76%, 30.96%, 49.54% and 51.35% respectively. The mechanism of gastric ulcer healing is not well understood and further study is needed to evaluate the specific phytoconstituents responsible for the gastric ulcer healing but on the basis of present study it can be concluded that this gastric healing potential may be due to the pharmacological effect played by the different phytoconstituents present in the ethanolic extract of Brassica nigra leaves for prevention of gastric mucosa or by the antioxidant potential of the leaves which is evaluated during the DPPH free radical scavenging activity.</p></td></tr></tbody></table>

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Section: Antiulcer Activitymentioning

confidence: 99%

Antioxidant and Antiulcer Potential on leaves of Brassica nigra L. against Gastric Ulcer

Tripathi

Punekar²,

Jain

et al. 2017

ijpm

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Risk factors for delayed healing in venous leg ulcers: a review of the literature

et al. 2015

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Predicting delayed healing: The diagnostic accuracy of a venous leg ulcer risk assessment tool

Edwards

Parker

Miller

et al. 2017

International Wound Journal

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The aim of this study was to validate a newly developed tool that can predict the risk of failure to heal of a venous leg ulcer in 24 weeks. The risk assessment tool was validated, and performance of the tool was assessed using Area Under the Receiver Operating Characteristic Curve (AUC) analysis. Retrospective and prospective validation was conducted through multi-site, longitudinal studies. In the retrospective study (n = 318), 30% of ulcers did not heal within 24 weeks, with the tool demonstrating an AUC of 0.80 (95% CI, 0.68-0.93, P < .001) for the total score. In the prospective study across 10 clinical sites (n = 225), 31% (n = 68) of ulcers did not heal within 24 weeks. Participants were classified with the RAT at enrolment as being at low risk (27%), moderate risk (53%) or high risk (20%) of delayed healing; the proportion of wounds unhealed at 24 weeks was 6%, 29% and 59%, respectively. Validation results of the total score indicated good discrimination and goodness of fit with an AUC of 0.78 (95% CI, 0.71-0.85, P < .001). Validation of this risk assessment tool offers assurance that realistic outcomes can be predicted for patients, and scores can guide early decisions on interventions to address specific risk factors for failing to heal, thus promoting timely healing.

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A severity score comprising patient age, ulcer chronicity, and venous refill time predicted venous leg ulcer healing at 24 weeks

Cited by 5 publications

References 4 publications

Antioxidant and Antiulcer Potential on leaves of Brassica nigra L. against Gastric Ulcer

Antioxidant and Antiulcer Potential on leaves of Brassica nigra L. against Gastric Ulcer

Risk factors for delayed healing in venous leg ulcers: a review of the literature

Predicting delayed healing: The diagnostic accuracy of a venous leg ulcer risk assessment tool

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