A severity score for spontaneous canine acute pancreatitis

Ruaux, Craig G.; Atwell, R. B.

doi:10.1111/j.1751-0813.1998.tb12331.x

Cited by 45 publications

(58 citation statements)

References 6 publications

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“…Previous reports have suggested that assessing the severity of AP using pancreatic enzyme activity potentially is inaccurate. In 1 report, the use of a severity score based upon organ system compromise was more accurate in determining the likelihood of mortality in AP . The CRP concentration appeared to be associated with disease severity.…”

Section: Discussionmentioning

confidence: 95%

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Clinical Utility of Diagnostic Laboratory Tests in Dogs with Acute Pancreatitis: A Retrospective Investigation in a Primary Care Hospital

Yuki

Hirano

Nagata

et al. 2015

Veterinary Internal Medicne

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BackgroundAcute pancreatitis (AP) occurs frequently in dogs, but most previous studies examining the diagnosis of AP have used data from secondary care hospitals.Hypothesis/ObjectivesThe aim of this study was to investigate the clinical utility of diagnostic laboratory tests in dogs with AP in a primary care hospital.AnimalsSixty‐four dogs with clinical signs suggestive of AP diagnosed with nonpancreatic disease (NP) or AP.MethodsMedical records were retrospectively reviewed, including diagnostic laboratory tests considered potentially useful in the diagnosis of AP. The diagnostic accuracy of amylase and FUJI DRI‐CHEM lipase (FDC lip) were investigated using receiver operating characteristics (ROC). In addition, we verified whether diagnostic laboratory tests were useful for evaluating duration of hospitalization and as biomarkers for monitoring recovery.ResultsActivities of amylase and FDC lip were significantly higher in the AP group than in the NP group (P = .001, P < .001, respectively). The sensitivity of FDP lip activity for diagnosing AP was 100% (95% confidence interval [CI], 87.7–100%); the specificity was 89.5% (95% CI, 66.9–98.7%). Area under the ROC curve for FDC lip activity was 0.98 (95% CI, 0.93–1). High alanine aminotransferase (ALT) activity was associated with extended duration of hospitalization (P = .04). A significant difference in C‐reactive protein (CRP) concentration before and 5 days after treatment was found (P = .001).Conclusions and clinical importanceMeasurement of FDC lip activity appears useful for diagnosing AP. High ALT activity might be associated with prolonged duration of hospitalization, and CRP might be useful as a biomarker for monitoring recovery from AP.

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Section: Discussionmentioning

confidence: 95%

“…In 1 report, the use of a severity score based upon organ system compromise was more accurate in determining the likelihood of mortality in AP. 25 The CRP concentration appeared to be associated with disease severity. In another study, no relationship was observed between CRP concentration and outcome.…”

Section: Discussionmentioning

confidence: 97%

Clinical Utility of Diagnostic Laboratory Tests in Dogs with Acute Pancreatitis: A Retrospective Investigation in a Primary Care Hospital

Yuki

Hirano

Nagata

et al. 2015

Veterinary Internal Medicne

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“…Further studies are needed to investigate the relationship between CIRCI and AP in dogs. Ruaux & Atwell (1998) proposed a system for rating the clinical severity of AP on a scale ranging from 0 to 4, indicating the number of organs other than the pancreas exhibiting signs of compromise or failure. In this system, the BUN, CRE, ALP, ALT, GLU and WBC count are used to predict prognosis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs

Okanishi

Nagata²,

Nakane³

et al. 2019

J of Small Animal Practice

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Objectives To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis. Materials and Methods Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis received treatment either with dose of 1 mg/kg/day prednisolone (n=45) or without prednisolone (n=20). Response to treatment was based on changes in the C‐reactive protein concentration, improvement in clinical signs, duration of hospitalisation, mortality and recurrence rate. Results From the third day of hospitalisation, C‐reactive protein concentration was significantly lower in the prednisolone group than that in the non‐prednisolone group. The number of days required to reach a C‐reactive protein concentration of <2 mg/dL and clinical score of ≤2 was significantly lower in the prednisolone group. The mortality rate 1 month after discharge was significantly lower in the prednisolone group (11.3% versus 46.1%). Clinical Significance In dogs with acute pancreatitis, initial treatment with prednisolone resulted in earlier reductions in C‐reactive protein concentration and earlier improvement of clinical signs.

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“…Therefore, individual measurements of Spec cPL or fPL concentrations cannot be used to determine the severity of pancreatitis. However, severity based on histopathologic features may not reflect clinical severity in animals with pancreatitis, and accurate assessment of clinical severity of pancreatitis is challenging . The utility of serum PLI concentration in determining the clinical severity of pancreatitis in dogs and cats requires evaluation in clinical studies in association with other markers of severity and using appropriate scoring systems for clinical severity.…”

Section: Pli As a Marker Of Severity In Pancreatic Diseasementioning

confidence: 99%

Canine and feline pancreatic lipase immunoreactivity

Xenoulis

Steiner

2012

Veterinary Clinical Pathol

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The diagnosis of pancreatitis in dogs and cats can be challenging. Several diagnostic tests have been evaluated over the years, but the majority have been shown to be of limited utility owing to poor performance or limited availability or because invasive procedures are required. Assays for the measurement of pancreatic lipase immunoreactivity (cPLI for dogs and fPLI for cats) were first developed over a decade ago and now include Spec cPL and SNAP cPL for dogs and Spec fPL and SNAP fPL for cats. Owing to their high sensitivity and specificity for pancreatitis compared with those of other serum tests, concentrations of cPLI and fPLI have been demonstrated to be the serum tests of choice for evaluation of dogs and cats, respectively, suspected of having pancreatitis. False-positive and false-negative results can occur, and recognition of the limitations of pancreatic lipase immunoreactivity assays is important. As there is currently no gold standard for antemortem diagnosis of pancreatitis in dogs and cats, the combination of a complete history and physical examination, measurement of pancreatic lipase immunoreactivity, and ultrasonographic examination of the pancreas is the best approach for an accurate noninvasive diagnosis of pancreatitis.

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A severity score for spontaneous canine acute pancreatitis

Cited by 45 publications

References 6 publications

Clinical Utility of Diagnostic Laboratory Tests in Dogs with Acute Pancreatitis: A Retrospective Investigation in a Primary Care Hospital

Clinical Utility of Diagnostic Laboratory Tests in Dogs with Acute Pancreatitis: A Retrospective Investigation in a Primary Care Hospital

Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs

Canine and feline pancreatic lipase immunoreactivity

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