A sexually dimorphic hypothalamic response to chronic high-fat diet consumption

Morselli, Eugenia; Frank, Aaron; Palmer, Biff F.; Rodríguez-Navas, Carlos; Criollo, Alfredo; Clegg, Deborah J.

doi:10.1038/ijo.2015.114

Cited by 64 publications

(50 citation statements)

References 36 publications

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“…The distribution of AIP by gender is presented in Figure 01 and Figure 02. http://dx.doi.org/10.15405/epsbs.2018.03.60 Corresponding Author: Marina Ruxandra Oțelea Selection and peer-review under Our result is in line not only with the previously recognized lower risk in women before menopause (Rossi et al, 2002;Pitha et al, 2014), but also with different nutrition influences related to gender (Morselli et al, 2015). Therefore, gender differences should be considered for both primary prevention and screening tests.…”

Section: Resultssupporting

confidence: 74%

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Oțelea¹

2018

The European Proceedings of Social and Behavioural Sciences

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Cardiovascular risk is based on age, gender, smoking, systolic blood pressure and total cholesterol.Although it is well documented that the atherosclerosis process starts early in life, the risk is very clearly defined only for fatal events and only for persons above 40 years old. Besides the Guidelines for the Management of Dyslipidaemias, other factors such as atherogenic plasma index (AIP) or adipokine levels have certain predictive information about this risk. The aim of our study was to assess the gender differences in AIP in a young non-obese adult population. We selected 85 young adults without a diagnosis of metabolic syndrome or related medical conditions. The metabolic syndrome components were measured and those (2 subjects) with 3 established metabolic syndrome criteria were excluded. The average AIP value on the whole group was 0.07. When stratifying the risk according to the AIP value, the majority of the participants were in the low risk range (51 participants representing 61.4% of the total), 18 (21.6%) were included in the high risk, and 15 (18%), in the medium risk category. The average AIP in women's group was 0.02, and in men's group, 0.18 (p<0.001). Our preliminary results suggest that, for screening purposes, the AIP threshold should be different according to gender. To confirm this finding, a large longitudinal study is needed.

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Section: Resultssupporting

confidence: 74%

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Oțelea¹

2018

The European Proceedings of Social and Behavioural Sciences

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“…Moreover, in response to HFD consumption, female rats gain less weight than males, but this differential response is no longer observed after ovariectomy (Stubbins et al 2012), which is similar to the tendency for postmenopausal women to increase their body weight as their estrogen levels decrease (Brown et al 2010, Hamilton et al 2016. In fact, females are reported to be more resistant to obesity than males in part due to the higher expression of ERα in astrocytes (Morselli et al 2015).…”

Section: Differences Between Males and Females In The Astrocytic Respmentioning

confidence: 48%

Glial cells and energy balance

Argente-Arizón

Guerra-Cantera

Garcia-Segura

et al. 2017

Journal of Molecular Endocrinology

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The search for new strategies and drugs to abate the current obesity epidemic has led to the intensification of research aimed at understanding the neuroendocrine control of appetite and energy expenditure. This intensified investigation of metabolic control has also included the study of how glial cells participate in this process. Glia, the most abundant cell type in the central nervous system, perform a wide spectrum of functions and are vital for the correct functioning of neurons and neuronal circuits. Current evidence indicates that hypothalamic glia, in particular astrocytes, tanycytes and microglia, are involved in both physiological and pathophysiological mechanisms of appetite and metabolic control, at least in part by regulating the signals reaching metabolic neuronal circuits. Glia transport nutrients, hormones and neurotransmitters; they secrete growth factors, hormones, cytokines and gliotransmitters and are a source of neuroprogenitor cells. These functions are regulated, as glia also respond to numerous hormones and nutrients, with the lack of specific hormonal signaling in hypothalamic astrocytes disrupting metabolic homeostasis. Here, we review some of the more recent advances in the role of glial cells in metabolic control, with a special emphasis on the differences between glial cell responses in males and females.

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“…In one study of healthy men, circulating LPS was increased with increased dietary energy, but not independently with other macronutrients (93). Interestingly, there is rodent data that males may be more susceptible to the pro-inflammatory effects of a high fat diet than females (125). …”

Section: Diet Modulates Absorption Of Bacterial Componentsmentioning

confidence: 99%

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Djurić

2017

Translational Research

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Obesity increases the risks of many cancers. One important mechanism behind this association is the obesity-associated pro-inflammatory state. Although the composition of the intestinal microbiome undoubtedly can contribute to the pro-inflammatory state, perhaps the most important aspect of host-microbiome interactions is host exposure to components of intestinal bacteria that stimulate the inflammatory reactions. Systemic exposures to intestinal bacteria can be modulated by dietary factors by altering both the composition of the intestinal microbiota as well as absorption of bacterial products from the intestinal lumen. In particular, high fat and high energy diets have been shown to facilitate absorption of bacterial lipopolysaccharide (LPS) from intestinal bacteria. Biomarkers of bacterial exposures that have been measured in blood include LPS-binding protein, sCD14, fatty acids characteristic of intestinal bacteria and immunoglobulins specific for bacterial LPS and flagellin. The optimal strategies to reduce these pro-inflammatory exposures, whether by altering diet composition, avoiding a positive energy balance or reducing adipose stores, likely differ in each individual. Biomarkers that assess systemic bacterial exposures therefore should be useful to optimize and personalize preventive approaches for individuals and groups with specific characteristics, and to gain insight into the possible mechanisms involved with different preventive approaches.

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A sexually dimorphic hypothalamic response to chronic high-fat diet consumption

Cited by 64 publications

References 36 publications

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Atherogenic Plasma Index in a Young Non-Obese Caucasian Population

Glial cells and energy balance

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

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