A shape healable tough hydrogel

Wang, Jilong; Su, Siheng; Hasan, Molla; Qiu, Jingjing; Wang, Shiren

doi:10.1039/c5nj01250c

Cited by 14 publications

(7 citation statements)

References 60 publications

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“…1 schematically shows the procedure of preparing physically cross-linked Agar/PVA DN gels using a simple solution blending method. First, agar and PVA were dissolved in hot water and formed linear random coil macromolecules [6,30] (Fig. 1 (a)).…”

Section: Design and Preparation Of Agar/pva Dn Gelsmentioning

confidence: 99%

“…1 (a)). Then, the resulting solution was cooled down to room temperature; a coil-to helix transition occurred in agar allowing the formation of first network via hydrogen bondassociated agar helix bundles [6,22,30] (Fig.1 (b)). Once the first agar network formed, the agar gel and PVA in the same pot were subjected to a freezing-thawing (F-T) cycle to form the second physically cross-linked network of PVA via the formation of large numbers of crystallites [31][32][33][34][35] (Fig.…”

Section: Design and Preparation Of Agar/pva Dn Gelsmentioning

confidence: 99%

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Bioinspired fully physically cross-linked double network hydrogels with a robust, tough and self-healing structure

Sabzi

Samadi

Abbasi

et al. 2017

Materials Science and Engineering: C

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The conventional covalently cross-linked double network (DN) hydrogels with high stiffness often show low toughness and self-healing property due to the irreversible bond breakages in their networks. Therefore, scarcity of hydrogels that possess simultaneous features of stiffness, toughness, and autonomous self-healing properties at the same time remains a great challenge and seriously limits their biomedical applications. While, many natural materials acquire these features from their dynamic sacrificial bonds. Inspired by biomaterials, herein we propose a novel strategy to design stiff, tough and self-healing DN gels by substitution of both covalently cross-linked networks with strong, dynamic hydrogen bond cross-linked networks. The prepared fully physically cross-linked DN gels composed of strong agar biopolymer gel as the first network and tough polyvinyl alcohol (PVA) biopolymer gel as the second network. The DN gels demonstrated multiple-energy dissipating mechanisms with a high modulus up to 2200kPa, toughness up to 2111kJm, and ability to self-heal quickly and autonomously with regaining 67% of original strength only after 10min. The developed DN gels will open a new avenue to hydrogel research and holds high potential for diverse biomedical applications, such as scaffold, cartilage, tendon and muscle.

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Section: Design and Preparation Of Agar/pva Dn Gelsmentioning

confidence: 99%

Section: Design and Preparation Of Agar/pva Dn Gelsmentioning

confidence: 99%

Bioinspired fully physically cross-linked double network hydrogels with a robust, tough and self-healing structure

Sabzi

Samadi

Abbasi

et al. 2017

Materials Science and Engineering: C

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“…Hydrogels, soft materials, are composed of hydrophilic polymeric chains, water and cross‐linkers, which have been widely fabricated and investigated in diverse areas, including soft machines, drug delivery, and tissue engineering . On the other hand, ion gels consisted of polymer matrix, ionic liquids, and crosslinkers have also been proposed as an alternative to liquid electrolytes in energy storage devices .…”

Section: Introductionmentioning

confidence: 99%

Super‐tough hydrogels using ionically crosslinked networks

Wang

Lou

Qiu

2019

J of Applied Polymer Sci

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Alginate and polyacrylamide hydrogels were produced by a facile one‐pot method with varied ionic crosslinkers in this article. These hydrogels display outstanding mechanical properties compared to the pristine polyacrylamide (PAAm) hydrogels. The alginate network is ionically crosslinked by multivalent cation, whereas N,N′‐methylenebis (acrylamide) (MBAA) is used as covalent crosslinker for the PAAm network. Particularly, the obtained hydrogels by using trivalent cations (Fe3+ and Al3+) as crosslinkers are much stronger than that of using divalent cations (Ca2+ and Ba2+) as crosslinkers. In addition, with increasing concentration of cations, the compressive properties of gels are improved, whereas when the concentration is higher than 0.3 M, the compressive properties of gels are damaged due to mono‐bindings. Interestingly, the hydrogels with higher chemical crosslinker concentration depicts better mechanical properties than those hydrogels with lower chemical crosslinker, which is different from that of common double network hydrogels. These hydrogels with excellent mechanical properties are promising candidates for biomedical application like load‐bearing tissues. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48182.

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“…Gels are one of promising candidates as scaffolds in tissue engineering. Double network (DN) gels combining two independently crosslinked networks are the common method to achieve tough hydrogels [8,9]. However, limited fatigue resistance extremely restricts its clinical applications [10,11].…”

Section: Introductionmentioning

confidence: 99%

Tough and Fatigue-Resistant Hydrogels with Triple Interpenetrating Networks

Wang

Qiu

2019

Journal of Nanomaterials

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Biomimetic hydrogels with triple networks have been developed via in situ polymerization and addition of graphene oxide (GO) nanosheets, which achieve improved toughness and superior fatigue resistance, simultaneously. Compared with pristine calcium alginate/polyacrylamide double network (DN) hydrogels, the integration of a calcium-induced graphene oxide network enhances the crosslinking degree of triple network (TN) hydrogels with improved compressive strength by 172% and toughness by 174%. In addition, cyclic compressive loading-unloading curves depict excellent fatigue resistance because of reversible calcium alginate and calcium-induced GO networks, whereas high strength and toughness of traditional DN gels derive from the first sacrificial network, which leads to inferior fatigue resistance. Toughness of these TN gels was still kept at 110 kJ m−3 at the fifth cycle which is equal to that of articular cartilages. The swelling property of these DN and TN hdyrogels is also systematically explored, which exhibits that GO can reduce the swelling to maintain the mechanical properties of TN gels. The internal fracture mechanisms of these TN hydrogels are studied via swelling tests of precompressed and as-prepared gels. These synergistic effects of the reversible ions crosslinking polymer network and nanofillers open a new platform to design supertough and fatigue-resistant hydrogels. In addition, these TN hydrogels are talented replacements for load-bearing parts, like cartilage due to its high toughness and superior fatigue resistance.

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A shape healable tough hydrogel

Abstract: The artificial meniscus made by a double network hydrogel was recovered by a two-step healing process.

Cited by 14 publications

References 60 publications

Bioinspired fully physically cross-linked double network hydrogels with a robust, tough and self-healing structure

Bioinspired fully physically cross-linked double network hydrogels with a robust, tough and self-healing structure

Super‐tough hydrogels using ionically crosslinked networks

Tough and Fatigue-Resistant Hydrogels with Triple Interpenetrating Networks

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