A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

Abstract

We previously demonstrated that for long-term spastic limb paralysis, transferring the seventh cervical nerve (C7) from the nonparalyzed side to the paralyzed side results in increase of 17.7 in Fugl-Meyer score. One strategy for further improvement in voluntary arm movement is selective activation of five target muscles innervated by C7 during recovery process. In this study, we develop an implantable multisite optogenetic stimulation device (MOSD) based on shape-memory polymer. Two-site stimulation of sciatic nerve bundles by MOSD induces precise extension or flexion movements of the ankle joint, while eight-site stimulation of C7 nerve bundles induce selective limb movement. Long-term implant of MOSD to mice with severed and anastomosed C7 nerve is proven to be both safe and effective. Our work opens up the possibility for multisite nerve bundle stimulation to induce highly-selective activations of limb muscles, which could inspire further applications in neurosurgery and neuroscience research.

Compliant peripheral nerve interfaces

“…A more adequate solution for chronic experiments consists in directly integrating the light source on the device, using bare micro-LED dies placed on flexible substrates, either through wire bonding or surface mount technology [172,[175][176][177][178][179]. These miniaturized components feature a relatively low power consumption, which makes it possible to employ wireless operation, whether it is through the use of an RF harvesting unit and rectifier circuit for power and data transmission [176] or through the use of a battery-powered headstage component [179].…”

“…Similarly to electrical extraneural devices, optical cuffs cannot achieve the same level of localized light delivery as intraneural devices. They therefore require optimization of stimulation parameters to target fibers located within the nerve, by modulating the amplitude of current applied to LEDs in order to access either superficial or deeper structures [172].…”

Cerebral Injury Promotes Regeneration of The Brachial Plexus

“…Two weeks after TBI or sham TBI surgery, brachial plexus injury was induced. An anesthetized mouse was placed in the beach-chair position, and the brachial plexus was exposed as described in our previous study (18). The C5-T1 nerves on the right side were transected, and only the C7 nerve was sutured.…”

Self‐Bondable and Stretchable Conductive Composite Fibers with Spatially Controlled Percolated Ag Nanoparticle Networks: Novel Integration Strategy for Wearable Electronics

“…However, after optimizing the mass ratios of the base materials, an additional heat-rolling process was needed to obtain a highly stretchable and conductive nanocomposite. The lack of durable fiber-based interconnects to integrate fibrous components in supercapacitors, [20][21][22] lightemitting devices, [23][24][25] and energy generators, [26][27][28] remains a technological barrier. Various researchers have investigated electrical components with 1D configurations.…”