A short review of human exposure to antibiotics based on urinary biomonitoring

Yu, Hu; Zhu, Qingqing; Wang, Yawei; Liao, Chunyang; Jiang, Guibin

doi:10.1016/j.scitotenv.2022.154775

Cited by 36 publications

(16 citation statements)

References 138 publications

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“…8−11 The biomonitoring method is a feasible way to measure total exposure to antibiotics from clinical use, drinking water, and/or food and has been increasingly used in the epidemiological studies about environmental exposure to antibiotics. 12 A concern has arisen about the adverse effects of environmental exposure to antibiotics on human health. 11,12 Microbial metabolites deriving from gut microbiota are important signaling molecules connecting gut microbiota with human health.…”

Section: Introductionmentioning

confidence: 99%

“…12 A concern has arisen about the adverse effects of environmental exposure to antibiotics on human health. 11,12 Microbial metabolites deriving from gut microbiota are important signaling molecules connecting gut microbiota with human health. 13 Bile acids are a class of special metabolites, which closely interacts with gut microbiota by the enterohepatic circulation, 14−16 and their homeostasis plays a key role in human health.…”

Section: Introductionmentioning

confidence: 99%

“…Human exposure to antibiotics has been found to be associated with metabolic, immune, and psychological conditions (e.g., obesity, type 2 diabetes mellitus, asthma, and autism) and bacterial resistance by disrupting gut microbiota. − Due to a mass usage of antibiotics in humans and animals, the aquatic environment and food have been largely contaminated by antibiotics. − Besides the large-dose antibiotic exposure deriving from clinical use, humans can be environmentally exposed to low-level antibiotics through contaminated drinking water and/or food. − The biomonitoring method is a feasible way to measure total exposure to antibiotics from clinical use, drinking water, and/or food and has been increasingly used in the epidemiological studies about environmental exposure to antibiotics . A concern has arisen about the adverse effects of environmental exposure to antibiotics on human health. , …”

Section: Introductionmentioning

confidence: 99%

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Urinary Antibiotics and Bile Acid Homeostasis in Chinese Adults

Wang,

Zhao,

Jiang

et al. 2023

Environ. Sci. Technol. Lett.

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Bile acid homeostasis plays a key role in human health. Environmental exposure to antibiotics may influence bile acid homeostasis, but relevant data remain limited in human. We investigated 4247 adults in Shanghai, East China, and measured 31 antibiotics (six human antibiotics (HAs), 10 veterinary antibiotics (VAs), and 15 human/veterinary antibiotics (H/VAs)) and 10 typical bile acids transformed or untransformed microbially (chenodeoxycholic acid, cholic acid, lithocholic acid, ursodeoxycholic acid, and deoxycholic acid, and their respective species conjugated with glycine) in morning fasting urine. Eight concentration ratios of transformed to untransformed bile acids were constructed to indicate the microbial transformations of the bile acids. HAs, VAs, and H/VAs were, respectively, detected in 10.0%, 28.3%, and 58.1% urine samples with the 99th percentiles of creatinine-adjusted concentrations being 2.6 × 102 ug/g, 7.5 ug/g, and 3.2 × 102 ug/g, respectively. Multiple linear regression analysis showed that creatinine-adjusted concentrations of HAs, VAs, and H/VAs as well as eight typical antibiotics, including chlortetracycline, enrofloxacin, ciprofloxacin, ofloxacin, azithromycin, trimethoprim, chloramphenicol, and florfenicol, were associated with bile acids or decreased bile acid ratios. Environmental exposure to antibiotics was likely to disturb bile acid homeostasis in adults by affecting the microbial transformations of the bile acids.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary Antibiotics and Bile Acid Homeostasis in Chinese Adults

Wang,

Zhao,

Jiang

et al. 2023

Environ. Sci. Technol. Lett.

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“…Liquid chromatography-tandem mass spectrometry (LC–MS/MS), enzyme-linked immunoassay (ELISA), and microbiological detection methods are used for the detection of antibiotics. − These methods are sensitive and accurate, but LC–MS/MS is expensive and complex and has high detection limits, and ELISA and microbiological assays are too complex, limiting their application. Recently, fluorescent sensors, which are simple to operate and have very high sensitivity and short response times, have become an essential technology for analyte detection.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Ratiometric Fluorescent Flexible Sensor Based on the RhB@ZIF-8@PVDF Mixed-Matrix Membrane for Broad-Spectrum Antibiotic Detection

Xu,

Tang,

Jiang

et al. 2023

ACS Appl. Mater. Interfaces

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Antibiotics play an essential role in the treatment of various diseases. However, the overuse of antibiotics has led to the pollution of water bodies and food safety, affecting human health. Herein, we report a dual-emission MOF-based flexible sensor for the detection of antibiotics in water, which was prepared by first encapsulating rhodamine B (RhB) by a zeolite imidazolium ester skeleton (ZIF-8) and then blending it with polyvinylidene difluoride (PVDF). The luminescent properties, structural tunability, and flexible porosity of the MOF-based composites were combined with the processability and flexibility of polymers to prepare luminescent membranes. The sensor is capable of dual-emission ratiometric fluorescence sensing of nitrofurantoin (NFT) and oxytetracycline (OTC), exhibiting sensitive detection of fluorescence burst and fluorescence enhancement, respectively, with detection limits of 0.012 μM and 8.9 nM. With the advantages of visual detection, high sensitivity, short detection time, and simplicity, the highly sensitive ratiometric fluorescent flexible sensor has great potential for detecting antibiotics in an aqueous environment. It will further stimulate interest in luminescent MOF-based mixed matrix membranes and their sensing applications.

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“…Antibiotics are an emerging group of water contaminants that pose serious ecological and health risks. Efficient monitoring systems based on sensors are needed to monitor their occurrence concentration and spatial distributions in the water environment. , To overcome the limitations of conventional instrumental analysis, e.g., chromatography and spectroscopy methods, with demerits of being time-consuming and lack of portability, , FET sensors based on 2D semiconductors ( e.g. , graphene and MoS 2 ) have been developed for rapid and on-site detection of antibiotics. , In addition to the channel material, the functionalization of sensing probes on the channel surface that can specifically bind or interact with target molecules plays a vital role in selective detection.…”

mentioning

confidence: 99%

Highly Specific Antibiotic Detection on Water-Stable Black Phosphorus Field-Effect Transistors

Chen

Yuan

et al. 2023

ACS Sens.

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Two-dimensional (2D) black phosphorus (BP) has been reported to have appealing semiconducting properties as the sensing channel in field-effect transistor (FET) sensors. However, the intrinsic instability of BP in water greatly hinders its application, and little is known about its sensing performance and mechanism in aqueous medium. Herein, a water-stable BP FET sensor for antibiotic detection is reported. A novel surface engineering strategy with Ag+ coordination and melamine cyanurate (MC) supramolecular passivation is utilized to enhance the stability and transistor performance of BP. With molecularly imprinted polymers (MIPs) as the detection probe for tetracycline, the BPAg(+)/MC/MIPs sensor shows high sensitivity to tetracycline with a detection limit of 7.94 nM and a quick response within 6 s as well as high selectivity against other antibiotics with similar molecular structures. A new sensing mechanism relying on the conjugation effect of the probe structure is proposed, and new knowledge about alkalinity-enhanced and ionic strength-related response from the electrostatic gating effect is given based on the solution chemistry impact study. This work offers an efficient surface engineering strategy to enable the application of 2D BP for antibiotic detection in aqueous medium and presents a new sensing mechanism in chemical analysis by FET sensors.

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A short review of human exposure to antibiotics based on urinary biomonitoring

Cited by 36 publications

References 138 publications

Urinary Antibiotics and Bile Acid Homeostasis in Chinese Adults

Urinary Antibiotics and Bile Acid Homeostasis in Chinese Adults

Highly Sensitive Ratiometric Fluorescent Flexible Sensor Based on the RhB@ZIF-8@PVDF Mixed-Matrix Membrane for Broad-Spectrum Antibiotic Detection

Highly Specific Antibiotic Detection on Water-Stable Black Phosphorus Field-Effect Transistors

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