A short review on chemical properties, stability and nano-technological advances for curcumin delivery

Slika, Layal; Patra, Digambara

doi:10.1080/17425247.2020.1702644

Cited by 76 publications

(35 citation statements)

References 119 publications

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“…Despite the outstanding and multiple therapeutic properties of curcumin, there is a major limitation that restricts its therapeutic use, its poor pharmacokinetic properties, low aqueous solubility, low metabolic stability, and low oral bioavailability [52]. This promoted important research efforts to improve its therapeutic profile while keeping the beneficial biological properties, like modification of its chemical structure leading to the preparation of different curcuminoids.…”

Section: Design and Synthesis Of New Curcumin Derivativesmentioning

confidence: 99%

Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators

Ximenis

Mulet²,

Sala³

et al. 2021

IJMS

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The α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain, and inflammation. Allosteric modulation of this receptor might be advantageous to reduce the toxicity in comparison with full agonists. Our previous results obtained with some hydroxy-chalcones, which were identified as positive allosteric modulators (PAMs) of α7 nAChR, prompted us to evaluate the potential of some structurally related naturally occurring flavonoids and curcuminoids and some synthetic curcumin analogues, with the aim of identifying new allosteric modulators of the α7 nAChR. Biological evaluation showed that phloretin, demethoxycurcumin, and bis-demethoxicurcuming behave as PAMs of α7 nAChR. In addition, some new curcumin derivatives were able to enhance the signal evoked by ACh; the activity values found for the tetrahydrocurcuminoid analog 23 were especially promising.

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Section: Design and Synthesis Of New Curcumin Derivativesmentioning

confidence: 99%

Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators

Ximenis

Mulet²,

Sala³

et al. 2021

IJMS

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“…These synthetic curcumin-metal molecules entrapped into nanoliposomes will be a good source of curcumin and metal for meeting many nutritional requirements of the body. Further, these synthetic lipocurcumins' oxidative degradation pattern can be analyzed with in-vivo kinetic studies 33,34 . The results obtained then, on comparison with the sequence of degradation of natural curcumin will definitely lay a fire in the arena of curcumin research.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2021

IJPSR

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“…The chemical properties of curcumin have been previously well described. This compound shows three chemical components in its structure, including one diketone moiety and two more stable phenolic groups [108,109]. The stability and the effectiveness of curcumin for therapeutic applications may be influenced by several parameters of the biological environment including light exposure, temperature, and pH [108].…”

Section: Curcumin and Microgliamentioning

confidence: 99%

Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

et al. 2022

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Inflammaging is a term used to describe the tight relationship between low-grade chronic inflammation and aging that occurs during physiological aging in the absence of evident infection. This condition has been linked to a broad spectrum of age-related disorders in various organs including the brain. Inflammaging represents a highly significant risk factor for the development and progression of age-related conditions, including neurodegenerative diseases which are characterized by the progressive dysfunction and degeneration of neurons in the brain and peripheral nervous system. Curcumin is a widely studied polyphenol isolated from Curcuma longa with a variety of pharmacologic properties. It is well-known for its healing properties and has been extensively used in Asian medicine to treat a variety of illness conditions. The number of studies that suggest beneficial effects of curcumin on brain pathologies and age-related diseases is increasing. Curcumin is able to inhibit the formation of reactive-oxygen species and other pro-inflammatory mediators that are believed to play a pivotal role in many age-related diseases. Curcumin has been recently proposed as a potential useful remedy against neurodegenerative disorders and brain ageing. In light of this, our current review aims to discuss the potential positive effects of Curcumin on the possibility to control inflammaging emphasizing the possible modulation of inflammaging processes in neurodegenerative diseases.

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A short review on chemical properties, stability and nano-technological advances for curcumin delivery

Cited by 76 publications

References 119 publications

Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators

Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators

Untitled

Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

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