A short review on selena and tellurasteroids

Abstract

Recently hetero steroids have received much attention for pharmacological interest. Indeed, the replacement of one or more carbon atoms of a steroid molecule by a heteroatom often results in useful alterations to its biological activity because this modification affects the chemical properties of this steroid. Compounds containing a selenium, or a tellurium atom can possess biological properties and so have a great potential for the creation of a new library of molecules important for biological applications. Some of them have been used as antibacterial, antiviral, antihypertensive, or chemopreventive anticancer agents. Recent developments in the syntheses of selena and tellurasteroids are described herein.

Steroids Bearing Heteroatom as Potential Drugs for Medicine

“…Due to the toxicity of tellurium, the synthesis and study of tellurium-containing steroids require careful handling and safety precautions. The incorporation of tellurium into steroid molecules (268-280, as shown in Figure 43) introduces unique chemical properties and potential biological activities, which make these compounds of interest in medicinal chemistry and related fields [336].…”

“…Due to the toxicity of tellurium, the synthesis and study of tellurium-containing steroids require careful handling and safety precautions. The incorporation of tellurium into steroid molecules (268-280, as shown in Figure 43) introduces unique chemical properties and potential biological activities, which make these compounds of interest in medicinal chemistry and related fields [336]. However, it is important to note that the research on steroids bearing tellurium atoms is limited, and their specific biological activities and potential applications are still being explored.…”

“…While our research may not directly delve into organotellurium chemistry, the significance of tellura steroids and their potential impact on medicine and pharmacology cannot be overlooked. Continued investigations in this area may lead to the discovery of new bioactive compounds and further our understanding of the role of tellurium-containing compounds in various biological processes [332,336,337].…”

“…Biological activities of titanocene steroid conjugates(332)(333)(334)(335)(336)(337)(338)(339) [370].…”