A signal-on electrochemiluminescence immunosensor for A2780 cell detection based on the excellent catalytic performance of Co²⁺ doped TiO₂ nanodisks

Abstract

This work aimed at developing a new ovarian cancer cell analysis platform based on the metal organic frameworks derived Co2+ doped TiO2 nanodisks (Co-TiO2 NDs) mediated cathode electrochemiluminescence (ECL) of...

Functionalized metal–organic frameworks based on multi-catalyst ordered assembly for electrochemical stripping chemiluminescent immunoassay

“…However, under neutral conditions, the reaction rate of the luminol-H 2 O 2 system is slow, and only a quite low ECL signal can be generated, which is unfavorable to the requirement of common highly sensitive ECL analysis and detection. To date, several reports have confirmed that the ECL signal of the luminol-H 2 O 2 system can be effectively amplified by catalysts, such as metal ions, 19 porphyrins and their derivatives, 20,21 metal nanoparticles and clusters, 22,23 quantum dots, 24 carbon nanomaterials, 20,22,25,26 etc. Therefore, how to make full use of the existing catalytic system and construct a more efficient catalytic mechanism is of great significance to improve the ECL efficiency of the luminol-H 2 O 2 system.…”

A sensitive electrochemiluminescence immunosensor for carbohydrate antigen 12-5 analysis based on dual-function SnO2 nanoflowers

“…Ovarian cancer is the main malignant tumor among gynecological cancers and has a high incidence worldwide, posing a serious threat to women's lives. 1,2 Women with ovarian cancer may not have any symptoms or only have slight symptoms up to the disease progression. Oncologists believe that detecting tumor markers is an important means of achieving early detection, diagnosis, treatment, and mortality reduction of ovarian cancer.…”