A significant linear association exists between nuchal translucency thickness and adverse perinatal outcome in euploid fetuses

Sheizaf, Boaz; Fink, Miriam; Hershkovitz, Reli; Mazor, Moshe; Wiznitzer, Arnon

doi:10.1080/14767050802676717

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…Only few studies have linked increased NT in euploid fetuses with placental‐related adverse outcomes 25 ,. 26 Recently, a large cohort study assessed pregnancy outcomes in 260 unexplained increased nuchal translucency (i.e., fetal structural or chromosomal abnormalities) compared to 5749 normal NT pregnancies 27 . The study group had a slightly, but significantly higher rates of pre‐eclampsia ( p = 0.018), preterm birth ( p = 0.023), fetal growth restriction ( p = 0.032), and low birth weight ( p = 0.002).…”

Section: Discussionmentioning

confidence: 99%

Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology‐related complications

et al. 2021

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Objective: Identify placental pathology-related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis.Methods: A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3 mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013)(2014)(2015)(2016)(2017)(2018)(2019) in a single tertiary academic center. The following placental pathology-related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity.Results: A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental-related complications frequencies were higher in the study group, with a composite rate of 17.02% versus 6.52% in controls (p ¼ 0.042%). Secondary outcomes did not differ between groups. Conclusions:Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental-related complications. K E Y W O R D Schromosomal microarray analysis, fetus, nuchal translucency, placental complications Key PointsWhat's already known about this topic? � Pathological NT is considered to be related to genetic anomalies.

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Section: Discussionmentioning

confidence: 99%

Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology‐related complications

et al. 2021

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“…Increased NT in euploid fetuses can be due to heart defects, omphalocele, body stalk anomaly, skeletal defects; some genetic syndromes, such as congenital adrenal hyperplasia, fetal akinesia, or Noonan syndrome, have been suggested as possible causes. According to recent studies, a significant correlation has been found between increased NT and the presence of diaphragmatic hernia and a higher risk of cleft palate [12], [13], [14], [15].…”

Section: Possible Pathophysiological Mechanisms Arementioning

confidence: 99%

Increased Nuchal Translucency in Fetuses with Normal Karyotype

Anzhel,

Kovachev,

Zhekov

et al. 2024

Open Access Maced J Med Sci

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BACKGROUND: Increased nuchal translucency (NT) is associated with a high risk of chromosomal abnormalities and genetic syndromes. In fetuses with normal karyotype, thickened NT increases the likelihood of congenital heart malformations, spontaneous abortions, and stillbirths, especially in thickness > 3.5 mm. It was found that in the absence of accompanying structural abnormalities and a normal result of amniocentesis, the postnatal neurological development of the newborns did not differ from the general population. CASE PRESENTATION: The authors describe a case of sIUGR of monochorionic twins with second trimester selective umbilical cord ablation and livebirth of a healthy singleton. CONCLUSION: Abnormal NT thickness on early fetal morphology scan in euploid fetuses, especially in twin pregnancies, increase the suspicion for late complications of the pregnancy.

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“…Several studies have demonstrated that increased nuchal translucency (INT) is strongly associated with fetal cytogenetic disorders [1][2][3][4][5], especially trisomy 21 or 45, XO, and some specific fetal anomalies, in particular cardiac defects [3,6,7]. Additionally, INT in euploid fetuses or unexplained INT has been reported to be associated with various poor obstetric outcomes [8][9][10][11][12][13], including spontaneous abortion, low birth weight, preterm birth, fetal growth restriction, gestational diabetes mellitus, and preeclampsia. Nevertheless, most studies concerning effectiveness of NT measure-ments as a screening test of chromosome abnormalities or fetal cardiac defects are confined to the western world, the outcomes of NT screening in developing countries being reported rarely.…”

Section: Introductionmentioning

confidence: 99%

Increased nuchal translucency and fetal outcomes: a population-based study in Thailand

Traisrisilp¹,

Sirichotiyakul²,

Tongprasert³

et al. 2021

Clin. Exp. Obstet. Gynecol.

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Background: To determine the association between increased nuchal translucency (INT) and fetal outcomes among Thai population. Methods: A prospective database of fetal Down syndrome screening project was accessed to enable retrieval of the records of any women with recorded NT measurements. The selected pregnancies were categorized into the INT group (>95th percentile) and the normal (<95th percentile) group. The effectiveness of NT for prediction of Down syndrome and hemoglobin Bart's disease was also determined. Pregnancy outcomes were compared, also using multivariate analysis to correct the major confounders. Results: Out of 8225 NT measurements recorded, data from 7126 fetuses were available for analysis. These included 357 in the INT group and 6769 in the normal group. INT was significantly associated with Turner syndrome, Down syndrome, Edwards' syndrome, Patau syndrome, cardiac defect and Hb Bart's disease. After exclusion of fetal abnormalities, rates of abortion, low birth weight (LBW), preterm birth and intrauterine death (IUD) were significantly higher in the INT group, with adjusted odds ratio (95% CI) of 7.82 (7.48-13.66), 0.60 (0.42-0.86) and 5.10 (1.11-23.42), respectively. INT was effective in predicting Down syndrome with a sensitivity of 61.1% with a false positive rate of 5%. Conclusions: In addition to effectiveness in screening aneuploidy and cardiac defect, INT significantly increased the identification of risk of some diseases specific to a certain geographical area, for example Hb Bart's disease in Thailand. Among the euploid fetuses in this study the rate of abortion, LBW, preterm birth and IUD were also significantly increased.

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A significant linear association exists between nuchal translucency thickness and adverse perinatal outcome in euploid fetuses

Abstract: A linear association exists between NT thickness in chromosomally and structurally normal fetuses, and the risk for gestational diabetes and perinatal mortality.

Cited by 7 publications

References 28 publications

Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology‐related complications

Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology‐related complications

Increased Nuchal Translucency in Fetuses with Normal Karyotype

Increased nuchal translucency and fetal outcomes: a population-based study in Thailand

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