Recently, there has been a growing demand for wearable electronic devices/strain sensors in soft robotics body-health monitoring, human-machine interfaces and human motion detection. Wearable strain sensors feature fast and multi-stimuli sensitivity, high flexibility, ultra-stretchability and biocompatibility. Although the progress in flexible strain sensors is exponential, the production of wearable sensors undergoes several challenges, such as reliability and reproducibility. An in-depth understanding of the sensing mechanism of the flexible strain sensors based-polymeric nanocomposites is needed to fabricate reliable and reproducible sensors and move from the prototype phase into the industry phase. In this review, types of strain sensors and key parameters such as linearity, gauge factor (sensitivity), hysteresis and durability are explained in the context of the recently published work. In addition, current challenges and perspectives in relation to the wearable strain sensors are delineated.