A Silicon-based MEMS Vibrating Mesh Nebulizer for Inhaled Drug Delivery

Olszewski, Zbigniew; MacLoughlin, Ronan; Blake, Alan; O'Neill, M.; Mathewson, A.; Jackson, Nathan

doi:10.1016/j.proeng.2016.11.451

Cited by 36 publications

(21 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies revealed that aerosol droplet sizes have to be between 1 and 6 µm for an optimal effect. Droplets larger than 6 µm may deposit in the mouth or throat, droplets smaller than 1 µm can be exhaled, both cases lead to ineffectiveness [ 67 , 68 ]. According to literature, with PARI VELOX ® up to 75% of the produced aerosol droplets are smaller than 6 µm and the average volumetric-median-diameter of the aerosol droplets is 3.6 to 4.4 µm [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes

et al. 2021

View full text Add to dashboard Cite

Lung cancer is one of the most common causes for a high number of cancer related mortalities worldwide. Therefore, it is important to improve the therapy by finding new targets and developing convenient therapies. One of these novel non-invasive strategies is the combination of pulmonary delivered tetraether liposomes and photodynamic therapy. In this study, liposomal model formulations containing the photosensitiser curcumin were nebulised via two different technologies, vibrating-mesh nebulisation and air-jet nebulisation, and compared with each other. Particle size and ζ-potential of the liposomes were investigated using dynamic light scattering and laser Doppler anemometry, respectively. Furthermore, atomic force microscopy and transmission electron microscopy were used to determine the morphological characteristics. Using a twin glass impinger, suitable aerodynamic properties were observed, with the fine particle fraction of the aerosols being ≤62.7 ± 1.6%. In vitro irradiation experiments on lung carcinoma cells (A549) revealed an excellent cytotoxic response of the nebulised liposomes in which the stabilisation of the lipid bilayer was the determining factor. Internalisation of nebulised curcumin-loaded liposomes was visualised utilising confocal laser scanning microscopy. Based on these results, the pulmonary application of curcumin-loaded tetraether liposomes can be considered as a promising approach for the photodynamic therapy against lung cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Microdroplets can be formed either by atomizing bulk water (top down) with various methods such as high-pressure gas nebulization (15), ultrasonic nebulization (16), vibrating micromesh nebulization (17), and piezoelectric nebulization (18), or by condensing vapor-phase molecules (bottom up) (19). A question may be asked whether those unique properties of microdroplets arise only in microdroplets formed by atomization of bulk water.…”

mentioning

confidence: 99%

Condensing water vapor to droplets generates hydrogen peroxide

Lee

Han

Chaikasetsin

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

148

181

View full text Add to dashboard Cite

It was previously shown [J. K. Lee et al., Proc. Natl. Acad. Sci. U.S.A., 116, 19294–19298 (2019)] that hydrogen peroxide (H2O2) is spontaneously produced in micrometer-sized water droplets (microdroplets), which are generated by atomizing bulk water using nebulization without the application of an external electric field. Here we report that H2O2 is spontaneously produced in water microdroplets formed by dropwise condensation of water vapor on low-temperature substrates. Because peroxide formation is induced by a strong electric field formed at the water–air interface of microdroplets, no catalysts or external electrical bias, as well as precursor chemicals, are necessary. Time-course observations of the H2O2 production in condensate microdroplets showed that H2O2 was generated from microdroplets with sizes typically less than ∼10 µm. The spontaneous production of H2O2 was commonly observed on various different substrates, including silicon, plastic, glass, and metal. Studies with substrates with different surface conditions showed that the nucleation and the growth processes of condensate water microdroplets govern H2O2 generation. We also found that the H2O2 production yield strongly depends on environmental conditions, including relative humidity and substrate temperature. These results show that the production of H2O2 occurs in water microdroplets formed by not only atomizing bulk water but also condensing water vapor, suggesting that spontaneous water oxidation to form H2O2 from water microdroplets is a general phenomenon. These findings provide innovative opportunities for green chemistry at heterogeneous interfaces, self-cleaning of surfaces, and safe and effective disinfection. They also may have important implications for prebiotic chemistry.

show abstract

“…The changes in volume due to deformation of the apertures (∆V D ) was neglected for the calculations of the atomization rate, since it was very small compared to the total volume change ∆V e f f S . On the other hand, the pressure loss coefficient (ξ) is difficult to accurately assess its value, since the actual micro-apertures are manufactured by micro-abrasion electroforming and drilling techniques, which, in practice, give irregular conical shapes and edges [7]. Thus, in order to obtain an estimate of the approximate value of the loss coefficient (ξ a ), correlated to the experimental atomization rate (413 mg/min) obtained at 80 V and 110 kHz, the following procedure was implemented.…”

Section: Resultsmentioning

confidence: 99%

“…In particular, an ultrasonic atomization device is composed of a piezoelectric ceramic and a metal cover plate. It uses the piezoelectric effect and converts electrical energy into mechanical energy at a high-frequency resonance, causing the breakup of the liquid structure [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Vibration Analysis of a Piezoelectric Ultrasonic Atomizer to Control Atomization Rate

et al. 2021

View full text Add to dashboard Cite

In this work, a mechanical vibrational analysis of an ultrasonic atomizer is carried out to control its atomization mass transfer rate. An ultrasonic atomizer is a device constructed with a piezoelectric ring coupled to a metallic circular thin plate with micro-apertures. The mechanism of mass transfer by atomization is a complex phenomenon to model because of the coupling effect between the fluid transfer and dynamic mechanics controlled by a piezoelectric vibrating ring element. Here, the effect of the micro-apertures shape of the meshed thin plate coupled to a piezoelectric ring during vibration, as well as the resonance frequency modes, are numerically studied using a finite element analysis and compared with theoretical and experimental results. Good correlations between the predicted and experimental results of the resonant frequencies and atomization rates were found.

show abstract

A Silicon-based MEMS Vibrating Mesh Nebulizer for Inhaled Drug Delivery

Cited by 36 publications

References 5 publications

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes

Condensing water vapor to droplets generates hydrogen peroxide

Vibration Analysis of a Piezoelectric Ultrasonic Atomizer to Control Atomization Rate

Contact Info

Product

Resources

About