A silicone‐based controlled‐release device for accelerated proteolytic debridement of wounds

Bott, R. H.; Crissman, James W.; Kollar, Csilla; Saldajeno, M.; Ganshaw, G.; Thomas, Xavier; Lane, Thomas H.; Klykken, Paal C.; Davidson, Jeffrey M.; Nanney, Lillian B.

doi:10.1111/j.1524-475x.2007.00209.x

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Autolytic debridement is achievable through the use of moist interactive dressings including hydrogels (49), calcium alginates, hydrocolloids and films. Autolytic debridement removes non viable tissue through promoting the activities of phagocytic cells and endogenous enzymes, whereas enzymatic debridement requires exogenous agents such as proteolytic enzymes including collagenase, papain–urea and plant enzymes (fig and pineapple) (56–58). Desloughing may be hastened by lowering wound pH, but the use of acids (organic or inorganic) and other chemical agents is discouraged in light of the potential for pain.…”

Section: Consensus Statementsmentioning

confidence: 99%

Minimising wound‐related pain at dressing change: evidence‐informed practice

Woo

Harding

Price

et al. 2008

International Wound Journal

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Pain is a common concern in patients with chronic wounds. The purpose of this article is to inform clinicians of empirical evidence for practice based on a recent published consensus document on wound related pain. A team approach is needed to address the experience of living with wound related pain within a holistic framework. The importance of regular pain assessment and strategies to minimize traumatic during wound care are highlighted.

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Section: Consensus Statementsmentioning

confidence: 99%

Minimising wound‐related pain at dressing change: evidence‐informed practice

Woo

Harding

Price

et al. 2008

International Wound Journal

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“…The "reverse time-course" model eliminates the need for intermediate punch biopsies at each time point, reducing the risk of wound complications due to biopsy caused infection and inflammation. 37,38 Additional SFDI measurements were taken immediately postburn and after 1 h, but there was no histology to represent this time point. SFDI data were collected using the system described above (Fig.…”

Section: Preclinical Burn Modelmentioning

confidence: 99%

“…1(c)] heated to 100°C in boiling water. 37,38 The burn wounds in this study were imparted on the pig using a "reverse time course" model. On day 0, a total of six burn injuries were imparted on an animal; two wounds of each severity on either side of the animal (Fig.…”

Section: Preclinical Burn Modelmentioning

confidence: 99%

Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging

et al. 2014

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Abstract. The standard of care for clinical assessment of burn severity and extent lacks a quantitative measurement. In this work, spatial frequency domain imaging (SFDI) was used to measure 48 thermal burns of graded severity (superficial partial, deep partial, and full thickness) in a porcine model. Functional (total hemoglobin and tissue oxygen saturation) and structural parameters (tissue scattering) derived from the SFDI measurements were monitored over 72 h for each burn type and compared to gold standard histological measurements of burn depth. Tissue oxygen saturation (stO 2 ) and total hemoglobin (ctHbT) differentiated superficial partial thickness burns from more severe burn types after 2 and 72 h, respectively (p < 0.01), but were unable to differentiate deep partial from full thickness wounds in the first 72 h. Tissue scattering parameters separated superficial burns from all burn types immediately after injury (p < 0.01), and separated all three burn types from each other after 24 h (p < 0.01). Tissue scattering parameters also showed a strong negative correlation to histological burn depth as measured by vimentin immunostain (r 2 > 0.89). These results show promise for the use of SFDIderived tissue scattering as a correlation to burn depth and the potential to assess burn depth via a combination of SFDI functional and structural parameters. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…However, enzyme leakage does not negatively affect the planned ZP hydrogel application as wound dressings because the subtilisin DY which diffuses out from the hydrogel will go to the wound and will realize its debridement function there. For example, recently a silicon based dried emulsion for controlled release of proteolytic enzymes was introduced as a rapid enzymatic debridement device for cutaneous wound treatment . In summary, subtilisin DY activity when loaded into ZP hydrogels could ensure the enzymatic debridement during the wound dressing lifetime ensuring at the same time an effective wound exudate absorption due to its hydrogel nature.…”

Section: Resultsmentioning

confidence: 99%

“…For example, recently a silicon based dried emulsion for controlled release of proteolytic enzymes was introduced as a rapid enzymatic debridement device for cutaneous wound treatment. 21 In summary, subtilisin DY activity when loaded into ZP hydrogels could ensure the enzymatic debridement during the wound dressing lifetime ensuring at the same time an effective wound exudate absorption due to its hydrogel nature.…”

Section: Enzyme Activitymentioning

confidence: 99%

Polyzwitterionic hydrogels as wound dressings with enzymatic debridement functionality for highly exuding wounds

Ruseva

Nedkov

Alexandrova

et al. 2019

Polymer International

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Wound debridement is crucial for proper wound care as it promotes fast and efficient wound healing through removal of necrotic tissue. The latter not only impairs new healthy tissue formation but also increases the odour and the wound exudate, allowing bacteria and other harmful foreign invaders to spread and infect the wound. Hydrogel wound dressings are usually applied for promoting autolytic wound debridement but this is slow and not a very efficient process. On the other hand, enzymatic products for wound debridement are either ointments or gels and they are easily washed out when used for treating highly exuding wounds. This study is an attempt to combine enzymatic debridement functionality with the high swelling ability of polyzwitterionic networks and to produce an innovative dressing with debridement functionality for the healing of highly exuding wounds. For this purpose, two polyzwitterionic hydrogels were synthesized, poly(sulfobetaine methacrylate) and poly(carboxybetaine methacrylate) hydrogels, which were loaded with the protease subtilisin DY for imparting debridement functionality. The swelling ability and mechanical properties of zwitterionic polymer (ZP) hydrogels were shown to depend on their different propensities to physical network formation. Poly(carboxybetaine methacrylate) hydrogels demonstrated better capacity for wound exudate absorption as well as for exerting higher enzymatic debridement activity. Both ZP hydrogels were shown to be non‐cytotoxic which confirms their appropriateness for direct contact with injured tissues. Thus, the newly developed ZP hydrogels demonstrate the potential to be used as new dressing materials with enzymatic debridement functionality for highly exuding wounds. © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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A silicone‐based controlled‐release device for accelerated proteolytic debridement of wounds

Cited by 9 publications

References 26 publications

Minimising wound‐related pain at dressing change: evidence‐informed practice

Minimising wound‐related pain at dressing change: evidence‐informed practice

Noncontact imaging of burn depth and extent in a porcine model using spatial frequency domain imaging

Polyzwitterionic hydrogels as wound dressings with enzymatic debridement functionality for highly exuding wounds

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