A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: Comparative patient care audits

Fong, Joy Nolte; Wood, Fiona; Fowler, Barry

doi:10.1016/j.burns.2004.12.009

Cited by 99 publications

(75 citation statements)

References 20 publications

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“…More-stable antimicrobial activity of the agent used in dressings for chronic wounds leads to longer wear times and reduces the frequency of dressing changes. One of the desirable features of Acticoat, as proved by animal experiments and several clinical trials, is its extended wear time (51,56). Our results suggest that NxtSc-G5 has a similar possibility for extended wear time, as neither P. aeruginosa-nor S. aureusinfected wounds showed regrowth of these microorganisms 5 days after the application of NxtSc-G5 ( Fig.…”

Section: Discussionmentioning

confidence: 55%

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Miller

Tran

Haley

et al. 2014

Antimicrob Agents Chemother

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e Loss of the skin barrier facilitates the colonization of underlying tissues with various bacteria, where they form biofilms that protect them from antibiotics and host responses. Such wounds then become chronically infected. Topical antimicrobials are a major component of chronic wound therapy, yet currently available topical antimicrobials vary in their effectiveness on biofilmforming pathogens. In this study, we evaluated the efficacy of Next Science wound gel technology (NxtSc), a novel topical agent designed to kill planktonic bacteria, penetrate biofilms, and kill the bacteria within. In vitro quantitative analysis, using strains isolated from wounds, showed that NxtSc inhibited biofilm development by Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae by inhibiting bacterial growth. The gel formulation NxtSc-G5, when applied to biofilms preformed by these pathogens, reduced the numbers of bacteria present by 7 to 8 log 10 CFU/disc or CFU/g. In vivo, NxtSc-G5 prevented biofilm formation for 72 h when applied at the time of wounding and infection and eliminated biofilm infection when applied 24 h after wounding and infection. Storage of NxtSc-G5 at room temperature for 9 months did not diminish its efficacy. These results establish that NxtSc is efficacious in vitro and in vivo in preventing infection and biofilm development by different wound pathogens when applied immediately and in eliminating biofilm infection already established by these pathogens. This novel antimicrobial agent, which is nontoxic and has a usefully long shelf life, shows promise as an effective agent for the prevention and treatment of biofilm-related infections.

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Section: Discussionmentioning

confidence: 55%

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Miller

Tran

Haley

et al. 2014

Antimicrob Agents Chemother

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“…4,5 Furthermore, particular formulations that release silver continuously over 5-7 days reduced both pain and costs, because they require changing only once weekly. [6][7][8][9] However, different authors demonstrated that silver is cytotoxic in re-epitheliasing wounds by inhibiting cell proliferation and stimulating apoptosis. 10,11 Its use in superficial partial thickness burns seems excessive (low infection time) and dangerous (cytotoxic); in deep partial thickness burns, the outcome results from a balance between infection prevention and cell cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

Gravante

Montone

2010

annals

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Ann R Coll Surg Engl 2010; 92: 118-123 118Dressings have always been an important issue in reconstructive surgery to obtain better aesthetic and functional outcomes. This is particularly true in burns, where infections and contractures are more frequent than in other fields. Over latter years, pharmacological research has produced several products with different purposes: avoidance of infection (i.e. silvercontaining products), promotion of re-epithelialisation (alginates, hyaluronic acid-derived products), or both.In the ambulatory facility of our burn centre, we use different products for different purposes. Although we try to use them according to burn thickness and local status, no clear guideline exists and much of the decision is often left to the surgeon's personal experience. During the last days of 2005, new silver-based products (nanocrystalline silverActicoat, Smith and Nephew, and silver carboxymethylcellulose -Aquacel Ag, Convatec) were introduced in our clinical practice. In the present study, we analysed burn outcomes, in terms of healing times, during the last 2 months of 2005 and the first 2 months of 2006, to see if changes in wound care corresponded to an amelioration of healing times. We also tried to correlate eventual differences with those obtained from other products already in use. Patients and MethodsAfter local Institutional Review Board approval was obtained, we gathered data from patients treated in the ambulatory facility of our burn centre during the last 2 months of 2005 and the first 2 months of 2006. We excluded from the study: (i) admitted patients; (ii) patients with mixed superficial partial thickness and deep partial thickness burns; (iii) patients with full-thickness burns; and (iv) operated (2006, 19; 2005, 29 days; Student's t-test, P < 0.01). Among all dressings, paraffin gauzes had the shortest healing times in superficial burns (5 days); with silver-based dressings in deep burns, the healing times were nanocrystalline silver (16 days) and silver carboxymethylcellulose (21 days). CONCLUSIONS Results of our retrospective study would suggest that paraffin gauzes are a valuable option in superficial burns, while silver-based dressings are preferable in deep burns. RECONSTRUCTIVE SURGERY

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“…Various investigators demonstrated improved limb survival and functional outcomes for modular, metallic endoprostheses. [17][18][19] Since experience with these devices has grown and patient survival has increased, investigators are now able to systematically assess some of the underlying causes for reconstruction failure. Wirganowicz et al 20 addressed this issue by delineating reconstruction failure as mechanical vs nonmechanical.…”

Section: Failure Classifi Cation: Mechanical and Nonmechanicalmentioning

confidence: 99%

Advances in Segmental Endoprosthetic Reconstruction for Extremity Tumors: A Review of Contemporary Designs and Techniques

et al. 2011

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A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: Comparative patient care audits

Cited by 99 publications

References 20 publications

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

Advances in Segmental Endoprosthetic Reconstruction for Extremity Tumors: A Review of Contemporary Designs and Techniques

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