A simple and efficient approach for the synthesis of functionalized naphtho[2,1-b]furan via an one-pot, three-component reaction between Meldrum's acid, arylglyoxals, and β-naphthol

Abstract

A simple and efficient method for the synthesis of 2-(2-(aryl)naphtho[2,1-b]furan-1-yl)acetic acid derivatives via an one-pot three-component reaction of Meldrum's acid, arylglyoxals, and β-naphthol in the presence of triethylamine (Et3N) is reported. The protocol avoids the use of expensive catalysts, chromatographic separation and provides a wide range of novel naphtho[2,1-b]furans in excellent yields. Spectral data and elemental analysis have characterized the newly synthesized compounds.