A simple and efficient synthesis of [²H₁₀]deuterated bromfenvinphos by the Perkow reaction

Abstract

(E,Z)‐2‐bromo‐1‐(2,4‐dichlorophenyl)vinyl bis[ethyl‐2H5] phosphate ([2H10]bromfenvinphos), a regiospecifically deuterium‐labelled pesticide, was synthesized in two steps starting from [2H6]ethanol, phosphorus trichloride and 2,4‐dichlorophenacylidene bromide, and fully characterized. The deuterated biologically active bromfenvinphos is an important compound for the advancement of environmental degradation testing and some mass spectrometric studies. Copyright © 2011 John Wiley & Sons, Ltd.

A simple synthesis of the regiospecifically deuterium-labeled herbicide MCPA-isopropyl

“…1,3) In previous papers, we described both the identification and synthesis of some significant impurities, 4) as well as the synthesis of the regiospecifically deuterium-labeled insecticide bromfenvinphos. 5) A continuous interest in deuterated pesticides, led to our investigation of phenoxyacetic herbicides. MCPA-isopropyl (1) is a common name for the isopropyl ester of the widely known herbicide and plant growth regulator 4-chloro-2-methylphenoxyacetic acid (MCPA).…”