A Simple and Highly Sensitive Thymine Sensor for Mercury Ion Detection Based on Surface Enhanced Raman Spectroscopy and the Mechanism Study

Yang, Hao; Ye, Sui-Bo; Fu, Yu; Zhang, Weihong; Xie, Fangyan; Gong, L.; Chen, Jian; Tong, Yexiang

doi:10.3390/nano7070192

Cited by 18 publications

(5 citation statements)

References 39 publications

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“…(W. Wu et al, 2015) neurological disorders. A disposable SERS substrate developed by Yang et al, (H. Yang et al, 2017), as shown in Figure 24, by the deposition of thymine for simultaneous detection of Hg 2+ and Pb 2+ ions in drinking water employing oligonucleotide functionalized gold coated polystyrene microspheres (PSMPs). The LoD of the fabricated substrate was found to be 0.1ppb for Hg 2+ ions, which is far lower than the limit prescribed by the World Health Organization (WHO) (Guo et al, 2023).…”

Section: Heavy Metals and Other Small Moleculesmentioning

confidence: 99%

Recent advances in the design of SERS substrates and sensing systems for (bio)sensing applications: Systems from single cell to single molecule detection

Tadi,

Shenoy,

Bharadwaj

et al. 2024

F1000Res

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The Raman effect originates from spontaneous inelastic scattering of photons by matter. These photons provide a characteristic fingerprint of this matter, and are extensively utilized for chemical and biological sensing. The probability of generation, and hence the detection of these Raman scattered photons, is very low; hence, it is difficult to use this directly for sensing in complex matrices. To amplify this signal, surface-enhanced Raman spectroscopy (SERS) has been extensively investigated and has emerged as a powerful analytical tool for sensing diverse analytes, including ions, small molecules, inorganics, organics, radionucleotides, and cells. Plasmonic nanoparticles, called hotspots, exhibit localized surface plasmon resonance (LSPR). This amplifies the Raman signal and may offer up to a 1010-fold SERS signal enhancement. The development of SERS active substrates requires further consideration and optimization of several critical features such as surface periodicity, hotspot density, mitigation of sample or surface autofluorescence, tuning of surface hydrophilicities, use of specific (bio) recognition elements with suitable linkers and bioconjugation chemistries, and use of appropriate optics to obtain relevant sensing outcomes in terms of sensitivity, cross-sensitivity, limit of detection, signal-to-noise ratio (SNR), stability, shelf-life, and disposability. This article details the optimization of the aforementioned considerations in the use of disposable materials such as commercial grades of paper, textiles, glasses, polymers, and some specific substrates such as blue-ray digital versatile discs (DVDs) for use as SERS-active substrates for point-of-use (POU) sensing applications. The advancements in these technologies have been reviewed and critiqued for analyte detection in resource-limited settings, highlighting the prospects of applications ranging from single-molecule to single-cell detection.

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Section: Heavy Metals and Other Small Moleculesmentioning

confidence: 99%

Recent advances in the design of SERS substrates and sensing systems for (bio)sensing applications: Systems from single cell to single molecule detection

Tadi,

Shenoy,

Bharadwaj

et al. 2024

F1000Res

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“…The results revealed that the Hg 2+ ion sensor designed in this study had a detection limit and linearity comparable to those of recently reported sensors. [33][34][35][36][37][38][39] Table 1 shows the reported LOD values for detecting Hg 2+ ion using thymine-Hg 2+ -thymine pair strategies.…”

Section: Dependence Of Qcm Sensor Response On Hg 2+ Ion Concentrationmentioning

confidence: 99%

Strategic Approaches for Highly Selective and Sensitive Detection of Hg2+ Ion Using Mass Sensitive Sensors

Park

Lee

2019

ANAL. SCI.

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Here we present a quartz crystal microbalance (QCM) sensor for the highly selective and sensitive detection of Hg 2+ ion, a toxic chemical species and a hazardous environmental contaminant. Hg 2+ ion can be quantitatively measured based on changes in the resonance frequency of QCM following mass changes on the QCM sensor surface. The high selectivity for Hg 2+ ion in this study can be obtained using a thymine-Hg 2+-thymine pair, which is more stable than the adeninethymine base pair in DNA. On the other hand, gold nanoparticles (AuNPs) and their size-enhancement techniques were used to amplify the QCM signals to increase the sensitivity for Hg 2+ ion. With this strategic approach, the proposed QCM sensor can be used to quantitatively analyze Hg 2+ ion with high selectivity and sensitivity. The detection limit was as low as 98.7 pM. The sensor failed to work with other metal ions at concentrations 1000-times higher than that of the Hg 2+ ion. Finally, the recovery does not exceed 10% of the original value for the detection of Hg 2+ ion in tap and bottled water. The results indicate acceptable accuracy and precision for practical applications.

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“…Table shows examples of plasmonic‐nanomaterials used in heavy metal detection. Mercury species are among the most toxic pollutants for which SERS vestigial detection is of great interest but at the same time is quite challenging . Indirect methods for SERS detection of Hg 2+ have been described which use Raman reporters and also the T‐Hg 2+ ‐T base pair (T: thymine) approach (Figure ) .…”

Section: Sers and Water Quality Analysismentioning

confidence: 99%

Functionalized Inorganic Nanoparticles for Magnetic Separation and SERS Detection of Water Pollutants

et al. 2018

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Inorganic nanoparticles (NPs) have emerged in the last decades as key materials for a number of technologies. In particular, noble metal (Ag, Au) and iron oxide NPs have revealed important applications due to their plasmonic and magnetic properties, respectively. Among these applications, this review provides, on one hand, an overview on the use of colloidal metal NPs in surface enhanced Raman scattering (SERS) chemical analysis and, on the other hand, the application of iron oxides as a new class of nanosorbents for water pollutants. These distinct types of NPs are the main building blocks to produce [a] Raman spectroscopy is a powerful analytical tool for chemical characterization, providing information about molecular structure, surface processes, and interface reactions. [31,32] Raman spectroscopy is based on the inelastic scattering of photons by chemical species and materials (Raman scattering). Among the incident photons that hit the sample only a small portion is inelastically scattered, i.e. comes out at a different frequency from the incident light. The spectral information is based on the detection of these scattered photons that are recorded as energy shifts (Raman shifts) from the wavenumber of the elastic scattered photons (Rayleigh scattering). Each band in the Raman spectrum can be assigned to a vibrational mode (or Paula

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A Simple and Highly Sensitive Thymine Sensor for Mercury Ion Detection Based on Surface Enhanced Raman Spectroscopy and the Mechanism Study

Cited by 18 publications

References 39 publications

Recent advances in the design of SERS substrates and sensing systems for (bio)sensing applications: Systems from single cell to single molecule detection

Recent advances in the design of SERS substrates and sensing systems for (bio)sensing applications: Systems from single cell to single molecule detection

Strategic Approaches for Highly Selective and Sensitive Detection of Hg2+ Ion Using Mass Sensitive Sensors

Functionalized Inorganic Nanoparticles for Magnetic Separation and SERS Detection of Water Pollutants

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