A Simple and Highly Sensitive Turn-on Schiff Base Type Naked-eye Fluorescent Sensor for Aluminum Ion in Living Cells

Abstract

Six different Schiff bases to be used as turn-on fluorescent probes based on photoinduced electron transfer (PET) mechanism for the recognition of aluminum ions were successfully synthesized and characterized. The binding abilities of synthesized compounds with different metal cations were investigated by absorption and emission spectra. From the spectrophotometric experiments, it were seen that compound SK-1 displayed an excellent fluorescence response towards targeted aluminum ions probably due to its suitable chelating structure. Furthermore, such compound SK-1 also showed high sensitivity and selectivity response towards aluminum ions over other competing ions. In addition, the potential biological applications of SK-1 to detect aluminum ions in living cells were also investigated and results showed that fluorescence sensor SK-1 could be a promising probe for determining and/or monitoring aluminum ions in both biological and/or chemical samples.

Visible light‐triggered pyrazole‐functionalized reversible ionophore for selective monitoring of aluminium (III) ion

“…With Al 3+ , the interaction of S1 and Al 3+ becomes unnavigable to the PET and ESIPT processes, thereby turning on the remarkable fluorescence properties at 536 nm for S1. The recently reported observations by Peng et al, [48] Keskin et al [49] and Balagurusamy et al [50] strongly support this mechanism for the CHEF driven turn-on fluorescence for Al (III) ion recognition in solution. We surveyed the literature and made a comparison of detection efficiency (association constant) and detection limit with the reported structures (Table 2) [50][51][52][53][54][55][56][57][58][59][60][61] to understand the proficiency of the probe for selective detection of aluminium ions.…”

Synthesis and Spectroscopic Properties of Optical Probe Based on Schiff Base with Biological Application

“…While the phenolic OH proton at 14.19 ppm disappeared when added of 0.5 and 1.0 equiv. of Al 3+ to SB-2solution, the other signal at around 10.12and 9.61 ppm shifted to downfield (Keskin and Bayrakci, 2019). Also, the imine (CH=N) proton of SB-2 at 8.76 ppm was slightly shifted downfield.…”

A comparative study of two thienopyrimidine Schiff base probes for sequential monitoring of Ga3+ and Pd2+

“…However, the issue lies in the poor biocompatibility or insufficient water solubility of ordinary Schiff base molecules, which may impede their utility. While thienopyrimidine is generally considered vital as an intermediate in medicinal chemistry due to its excellent biocompatibility, it has displayed multifarious biological activities like antimalarial, anti-inflammatory, and antiviral effects [53,54]. Nevertheless, the potential of thienopyrimidine to serve as a fluorophore has not received much attention.…”