“…The slow onset of pain at four different intensity levels after standard arm exercise while the arterial supply is occluded has been used to demonstrate the effects of analgesics (Smith, Egbert, Marcowitz, Mosteller & Beecher, 1966; Smith et al, 1968) but few investigators have used it and it has not been proved to be repeatable. The same is true of inflating a sphygmomanometer cuff with internal projections (Poser, 1962). The application of chemicals to a blister produced by cantharidin (Armstrong, Dry, Keele & Monkham, 1953) is more a technique for studying peripheral mechanisms of nociception, but could be used to test analgesics.…”