2024
DOI: 10.1002/bmc.5959
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A simple and sensitive high‐performance liquid chromatographic method combined with fluorescence detection for bioanalysis of scopoletin in rat plasma: Application to a pharmacokinetic study

Taeyoung Kim,
Dong‐Gyun Han,
In‐Soo Yoon

Abstract: Scopoletin, a coumarin class natural phytoalexin, is present in medicinal plants such as noni (Morinda citrifolia). It exhibits diverse pharmacological properties, including antioxidant, anti‐hyperuricemic, and anti‐inflammatory effects. The objective of this study was to develop a novel HPLC‐fluorescence (HPLC‐FL) method for the quantitative analysis of scopoletin in the plasma and to investigate its pharmacokinetics in rats. Sample preparation involved a methanol‐based protein precipitation method, and chrom… Show more

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