The colour vision of 12 patients with tobacco amblyopia and 12 normal controls matched for age and sex was tested with the Pickford-Nicolson anomaloscope and the Farnsworth-Munsell 100-Hue test. The results of the two tests were correlated (p=+0.768, P < 0.01) in that the higher the matching range on the P-N anomaloscope, the greater is the error score on the 100-Hue test in tobacco amblyopia. The matching range (t = 9.78, P < 0.001) and the 100-Hue test (t = 5.43, P < 0.001) score were significantly higher than those of the controls. The acquired colour defect in tobacco amblyopia with the P-N anomaloscope is of extreme protanomalous type -the mean mid-matching point being shifted towards the red by more than the 3 x s.d. limits for the normal controls.