A Simple Assay for Direct Colorimetric Visualization of Trinitrotoluene at Picomolar Levels Using Gold Nanoparticles

Jiang, Ying; Zhao, Hong; Zhu, Ning; Lin, Yuqing; Yu, Ping; Mao, Lanqun

doi:10.1002/anie.200804066

Cited by 328 publications

(218 citation statements)

References 43 publications

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“…When analytes were added to a solution, these analytes interacted with the functional ligands adsorbed on the surface of Au NPs, resulting in the assembly of the Au NPs changing the solution color from red to blue (or purple). Many special ligands as analyte-receptors functionalized Au NPs were developed for the detection of ions [8][9][10][11][12][13][14][15][16][17] and small molecules [18][19][20][21]. For example, glutathione functionalized Au NPs for detection of Pb 2+ [10], mercaptopropionic acid for Hg 2+ [12], 5,5 -dithiobis(2-nitrobenzoic acid) for Cr 3+ [14], 1-(2-mercaptoethyl)-1,3,5-triazinane-2,4,6-trione for melamine [20].…”

Section: Introductionmentioning

confidence: 99%

A highly selective and sensitive colorimetric sensor for iodide detection based on anti-aggregation of gold nanoparticles

Chen

Lü

Wang

et al. 2013

Sensors and Actuators B: Chemical

104

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Section: Introductionmentioning

confidence: 99%

A highly selective and sensitive colorimetric sensor for iodide detection based on anti-aggregation of gold nanoparticles

Chen

Lü

Wang

et al. 2013

Sensors and Actuators B: Chemical

104

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“…12−26 However, the establishment of colorimetric assays for PFCs has not been reported yet. Actually, the applications of colorimetric assays based on Au NPs for environmental pollutants are scarce, and only very few colorimetric assays have been designed for TNT, 27,28 organophosphorus and carbamate pesticides, 29 and phthalates. 30 Selective isolation of fluorinated targets from convoluted mixtures has become increasingly popular using liquid−liquid separations, solid−liquid separations (such as fluorous solidphase extraction), and fluorous chromatography.…”

mentioning

confidence: 99%

Sensitive Colorimetric Visualization of Perfluorinated Compounds Using Poly(ethylene glycol) and Perfluorinated Thiols Modified Gold Nanoparticles

et al. 2014

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In this work, we have developed a novel sensing strategy employing mixed poly(ethylene glycol)-terminated (PEG-thiols) and perfluoroalkyl-terminated (F-thiols) alkanethiols modified gold nanoparticles (Au@PEG-F NPs) as a probe to detect perfluorinated compounds (PFCs) from water samples. PEG-thiols with high density and long carbon chains make the Au NPs probe well-dispersed in solution and stable even in high concentration of salt solution; F-thiols provide specific fluorous−fluorous interactions to PFCs, which results in adsorption of PFCs on Au@PEG-F NPs. The adsorbed PFCs cause the aggregation of Au@PEG-F NPs probes and thus induce the insolubility of probes and precipitation directly from reaction solution due to the superhydrophobicity of perfluorocarbon monolayers, leading to color and absorbance response of the assay to PFCs. The preparation of the Au@PEG-F NPs probe is very simple, and the colorimetric assay based on this mechanism for the detection of PFCs is selective and convenient. Combined with UV−vis spectrophotometry, the assay demonstrates good sensitivities to PFCs with wide linear range. In the designed concentration range, the response of the colorimetric assay to longchain PFCs (perfluoroalkyl chain ≥7) is discerned even as the concentration of these PFCs is as low as 10 μg L −1 . This low-cost and sensitive assay shows great potential to measure total PFCs in water samples. To the best of our knowledge, this is the first application of the specific fluorous−fluorous interactions and Au NPs based probes for colorimetric recognition for PFCs.

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“…As colorimetric probes, AuNPs have attracted great interests which can directly detect analytes by following the color change, using spectrophotometric method or even with naked eyes. Apparently, this method is of prime importance as no complicated instruments are needed in the detection procedures [15,16]. Moreover, the color change shows great sensitivity to the size, shape, capping agent, medium refractive index and state of AuNPs.…”

Section: Gold Npsmentioning

confidence: 99%

Drug Detection in Biological Specimens: Recent Colorimetric Methods

Hamidi

2018

Bioanalysis

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Recently, the detection approaches based on the metal nanoparticles (NPs) have attracted more and more attention due to their great extinction coefficient and strong surface plasma resonance properties. This report focuses on the present status of drug detection with metal NPs as ultrasmall labels in colorimetric-based methods. Although progresses have been emerged in drug detection, much work remains to be done to overcome the great challenges on sample preparation of complicated biological fluids. Plasmonic NPs can be combined with other existing functional groups to produce frameworks with novel multifunctional surface plasmon resonance for generating optical platform in drug detection. With their continued progress, we believe that making high quality and multifunctional plasmonic materials will play an important role in the drug detection and quantification in biological samples. Many important disciplines involving human health are dealing with the analysis of drugs present in living organisms or biological fluids. Biological samples are difficult to handle owing to their inherent complexity and, sometimes, sample preparation processes such as tryptic digestion make them even more complex. However, in the case of simpler matrices such as exhaled breath condensate, the direct injection of sample to analytical instruments is possible [1][2][3]. This complexity hinders the reliable analysis in two ways. First, most biological fluids are not amendable with analytical instruments since all biological samples consist of a vast range of ions, proteins, lipids, carbohydrates and so on, and cannot be injected to analytical devices. Second, highly abundant interfering compounds disturb the identification and quantification of trace analytes at subnanogram per milliliter levels.A bioanalytical strategy consists of two integral stages:r Sample preparation (treatment/cleanup/extraction) of the target analyte from its complex biological matrix; r Separation, detection and quantification of the analyte.Common technologies for drug determination in body fluids including ELISA, chromatographic and electrophoretic-based methods suffer from several limitations in bioanalytical laboratories. Owing to the complex matrix of most biological specimens, they rely on time-and labor-consuming sample purification. Moreover, sophisticated instruments such as MS are not affordable by many of the laboratories and require effective extraction approaches [4][5][6][7][8]. It is noteworthy that the sensitivity of some of these technologies is not adequate for detecting the required levels of target analyte. Therefore, there is still a great demand to develop inexpensive, fast, user-friendly and easy-to-operate technologies.The association of nanotechnology with medical treatment, including therapeutic drug monitoring, pharmacokinetic and pharmacodynamic studies has provided a new concept in drug detection. Label-free detection systems with little to no sample preparation is more appreciated [9]. Colorimetric methods use the intrinsic advant...

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A Simple Assay for Direct Colorimetric Visualization of Trinitrotoluene at Picomolar Levels Using Gold Nanoparticles

Cited by 328 publications

References 43 publications

A highly selective and sensitive colorimetric sensor for iodide detection based on anti-aggregation of gold nanoparticles

A highly selective and sensitive colorimetric sensor for iodide detection based on anti-aggregation of gold nanoparticles

Sensitive Colorimetric Visualization of Perfluorinated Compounds Using Poly(ethylene glycol) and Perfluorinated Thiols Modified Gold Nanoparticles

Drug Detection in Biological Specimens: Recent Colorimetric Methods

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