A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease

Tacke, Frank; Fiedler, Kai

doi:10.1080/00365520600930826

Cited by 30 publications

(25 citation statements)

References 28 publications

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“…Nine of 13 patients in this study had surgery for gastric varices. Bleeding from gastric varices is still diffi cult to control and has a high mortality rate, 21 whereas bleeding from esophageal varices can be controlled in more than 98% of patients using endoscopic treatment. 22 Primary bleeding from gastric varices is uncommon, occurring in 2%-5% of patients.…”

Section: Discussionmentioning

confidence: 99%

An assessment of surgery for portal hypertensive patients performed at a single community hospital

et al. 2010

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Section: Discussionmentioning

confidence: 99%

An assessment of surgery for portal hypertensive patients performed at a single community hospital

et al. 2010

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“…Liver cirrhosis, a malignant liver disease which is followed by liver failure resulting in high mortality, is also frequently associated with gastrointestinal (GI) complications such as GI bleeding and malnutrition [3,34,43]. Our previous studies showed that increased diversity of virulence factors and instability of the gut microecosystem are related to the severity of liver injury [27].…”

Section: Introductionmentioning

confidence: 97%

Assessment of the Fecal Lactobacilli Population in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis and Hepatitis B Cirrhosis Treated with Liver Transplant

Wang

Lü

et al. 2011

Microb Ecol

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This study aims to provide an overview of the diversity of intestinal Lactobacillus among Chinese patients with hepatitis B virus (HBV)-related decompensated cirrhosis and who received liver transplant for hepatitis B cirrhosis. Fecal samples were collected from 38 healthy volunteers, 61 patients with HBV-related decompensated cirrhosis (group LC) and 74 patients who had liver transplant for hepatitis B cirrhosis (group LT). Quantitative polymerase chain reaction technology with species-specific primers was applied to investigate lactobacilli 16S rDNA in crude DNA, extracted from fecal samples. Software package Statistical Package for the Social Sciences and Palaeontological Statistics for Windows was used to analyze the data. Lactobacilli population of the two patient groups was different from the healthy control subjects, principal differences being marked decrease in the population of Lactobacillus rhamnosus (p < 0.001 for both patient groups) and reduction in the frequency of Lactobacillus fermentus (p < 0.001 for group LC and p < 0.01 for group LT). Our findings on the frequency of lactobacilli population suggested decreased diversity in groups LC and LT (compared with the healthy controls (p < 0.001 and p < 0.01, respectively)). Patients tended to have less complex fecal lactobacilli composition than the healthy controls, especially in the group LC.

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“…Portal hypertension was established according to the following criteria: Portal vein diameter > 12 mm and/or presence of esophageal varices and/or splenomegaly. Alterations in the Quick index were established when the international normalized ratio (INR) was higher than 1.2 [33] . The ICG test was performed by pulsidensitometry (Limon PC5000, Pusion Medical Systems, Munich RFA).…”

Section: Methodsmentioning

confidence: 99%

Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?

Aparisi¹,

Sabater²,

Del-Olmo³

et al. 2008

WJG

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AIM:To study the possible association between chronic pancreatitis (CP) and liver cirrhosis (LC) of alcoholic etiology, after excluding any other causes. METHODS: One hundred and forty consecutive alcoholic patients were subdivided into three groups: CP (n = 53), LC (n = 57), and asymptomatic alcoholic (n = 30). Clinical, biochemical and morphological characteristics, Child-Pugh index, indocyanine green test, and fecal pancreatic elastase-1 test were assessed. RESULTS: In patients with cirrhosis, major clinical manifestations of CP such as pancreatic pain and steatorrhea, as well as imaging alterations of CP such as calcifications, duct dilation and pseudocysts were absent; insulin-dependent diabetes was present in 5.3% of cases, and elastase-1 test was altered in only 7%, and severely altered in none. In patients with CP, clinical characteristics of cirrhosis such as ascites, encephalopathy and gastrointestinal hemorrhage were present in one case, Child-Pugh grade > A in 5.7%, and altered indocyanine green test in 1.9% cases. In asymptomatic alcoholism, there was only a non-coincident alteration of elastase-1 test and indocyanine test in 14.8% and 10%, respectively, but other characteristics of cirrhosis or CP were absent. An inverse correlation (r = -0.746) between elastase-1 test and indocyanine test was found in alcoholic patients. CONCLUSION:There is a scarce coincidence in clinical and morphological alterations among patients with CP or LC of alcoholic etiology, but an inverse correlation between pancreatic and liver function tests. These findings support that these alcoholic diseases evolve in a different manner and have different etiopathogenesis.

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A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease

Abstract: A simple clinical score can predict the risk for upper GI bleedings in patients with chronic liver disease. This Bleeding Risk Score may help to supplement current endoscopic and clinical approaches to identify high-risk patients.

Cited by 30 publications

References 28 publications

An assessment of surgery for portal hypertensive patients performed at a single community hospital

An assessment of surgery for portal hypertensive patients performed at a single community hospital

Assessment of the Fecal Lactobacilli Population in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis and Hepatitis B Cirrhosis Treated with Liver Transplant

Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?

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