A simple Cu-64 production and its application of Cu-64 ATSM

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

“…A second method which can lead to carrier-free 64 Cu involves bombarding the target in a reactor with fast neutrons according to the nuclear reaction 64 Zn(n,p) 64 Cu. Two other methods involve the nuclear reaction 64 Ni(p,n) 64 Cu and 64 Ni(d,2n) 64 Cu,239,240 which can be carried out on a biomedical cyclotron to yield carrier-free copper-64, but an enriched nickel target must be irradiated to increase the yield of copper-64,241,242 and has spurred the development of 64 NiO targets to enhance 64 Ni recovery 243. Recently, Obata and colleagues described the production of 64 Cu using 12 MeV proton irradiation via 64 Ni(p,n) 64 Cu 244.…”

Detection of Increased 64Cu Uptake by Human Copper Transporter 1 Gene Overexpression Using PET with 64CuCl2 in Human Breast Cancer Xenograft Model

“…Radioactive copper ( 64 Cu) was produced from a 50-MeV cyclotron (Scantronics Co.) at the Korea Institute of Radiologic and Medical Sciences using enriched nickel ( 64 Ni, Isoflex Co., 99%) as the target material (15). The average specific activity of 64 Cu was 1,110 MBq (30 mCi) of copper per microgram in the form of CuCl 2 in 0.1 M HCl.…”

Targeted alpha immunotherapy of CD20-positive B-cell lymphoma model: Dosimetry estimate of 225Ac-DOTA-rituximab using 64Cu-DOTA-rituximab

“…64 CuCl2 was produced at the Korea Institute of Radiological and Medical Sciences (Seoul, Korea) by 50 MeV cyclotron irradiation [22]. The ratio of 64 CuCl 2 activity per DOTA-rituximab was determined to be 2 MBq per 1 mg. DOTA-rituximab conjugate was incubated with dried 64 CuCl2 in 1 mM sodium acetate buffer at 40 °C for 30 min.…”