A simple, efficient, one‐pot three‐component domino synthesis of Hantzsch pyridines under solvent‐free condition

Abstract

in Wiley InterScience (www.interscience.wiley.com).In this article, efficient and simple preparation of Hantzsch pyridine derivatives by reaction of various aldehydes and b-dicarbonyls in the presence of ammonium chlorate under solvent-free condition at 80 C is reported. The advantages of this system are the one-step procedure, high yields of the products, and the ability to carry out large-scale reactions.

Three‐Step Synthesis of Novel 2‐Aryl‐3‐benzamidobenzofurans: Regiospecific Reactions Catalyzed by Molybdate Sulfuric Acid

“…The advantages of solvent‐free procedures include cost savings, reduced energy consumption, decreased reaction times, and a considerable reduction in reactor size and, therefore, capital investment. These attributes have inspired a substantial research effort directed toward the development of solvent‐free reactions . Solid acid catalysts are interesting alternatives for the common liquid acids because of their simple handling and isolation of the reaction products and reagent .…”

Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process

“…At the same time, the oxidative aromatization of 1,4-dihydropyridines has also been extensively studied and numerous oxidizing reagents, namely, CuBr 2 [7], SiO 2 /P 2 O 5 -SeO 2 [8], H 2 O 2 /Co(OAc) 2 [9], and Na 2 S 2 O 4 /TBHP [10], have been used for the aromatization of 1,4-dihydropyridines. Some reports have observed that the direct oxidative procedure was very efficient for the preparation of Hantzsch pyridines under microwave-assisted condition or solventfree condition [11][12][13]. However, the search for the new readily available and green methods is still being actively pursued.…”

A Novel Approach for the Synthesis of 5‐Pyridylindolizine Derivatives via 2‐(2‐Pyridyl)pyridinium Ylides

“…Sequential transformations, multicomponent processes, and one‐pot procedures have become increasingly interesting because they offer simple and efficient synthetic ways to pyrroloazines .…”