A simple evaluation method for early detection of bisphosphonate-related osteonecrosis of the mandible using computed tomography

Hamada, Hayato; Matsuo, Akira; Koizumi, Toshiyuki; Satomi, Takafumi; Chikazu, Daichi

doi:10.1016/j.jcms.2014.01.012

Cited by 46 publications

(46 citation statements)

References 38 publications

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“…They found significantly more severe sclerosis in patients with BRONJ compared with the control group. It was also observed that the degree of sclerosis increased with the clinical stage of BRONJ, disagreeing with Hamada et al 38 Bone sclerosis, which is visualized as the loss of contrast definition between cortical bone and bone marrow space, 27,36 has been reported as the most significant early imaging sign of BRONJ. 16,19,27,29,30,36 It has been used as a criterion for non-exposed BRONJ because of its high prevalence at sites indicated by patients as symptomatic.…”

Section: Imaging Findingsmentioning

confidence: 62%

“…27,30,36,38,42,43 Nevertheless, according to some authors, all patients under bisphosphonate therapy should initially undergo panoramic radiography and afterwards further examinations if needed. 37,44 For the early detection of BRONJ, Hamada et al 38 recommend CT analysis of cancellous bone radiodensity. They believe that lack of bone exposure does not indicate an early stage of the disease, since no significant differences were found in radiodensity in images comparing Stage 0 with other stages.…”

Section: Imaging Findingsmentioning

confidence: 99%

“…On the basis of these assumptions, a new clinical variant of BRONJ has been suggested called non-exposed BRONJ, and more investigations have attempted to establish diagnostic criteria capable of providing early diagnosis and effective treatment 27,30,37,38 (Table 1).…”

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confidence: 99%

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Bisphosphonate-related osteonecrosis of the jaw: from the sine qua non condition of bone exposure to a non-exposed BRONJ entity

Koth¹,

Figueiredo²,

Salum³

et al. 2016

Dentomaxillofacial Radiology

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Section: Imaging Findingsmentioning

confidence: 62%

Section: Imaging Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Bisphosphonate-related osteonecrosis of the jaw: from the sine qua non condition of bone exposure to a non-exposed BRONJ entity

Koth¹,

Figueiredo²,

Salum³

et al. 2016

Dentomaxillofacial Radiology

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“…Morphological observations of cortical and cancellous bone structures using the CT images were first performed. Then, morphometrical measurements of bone structures were performed based on our previous papers …”

Section: Methodsmentioning

confidence: 99%

Long‐term structural changes and outcomes of implants in particulate cellular bone and marrow reconstructed jawbone

Matsuo

Hamada

Takahashi

et al. 2019

Clin Implant Dent Rel Res

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Background Association between long‐term structural changes of grafted bone and outcomes of the implants is not clear. Purpose Morphometrical measurements and implant success were analyzed in subjects of particulate cellular bone and marrow (PCBM) reconstruction of the jawbone. Materials and Methods Subjects were 30 implants in 13 patients from a series of 24 PCBM reconstruction cases. The cortical bone thickness and cancellous computed tomography (CT) radiodensity values were retrospectively analyzed from the CT data of 27 subjects. The cumulative success rate of the implants in the PCBM reconstructed cases (pure graft) was compared with that of 127 implants of 56 native bone cases and 42 implants of 28 bone augmentation (partial graft) cases. Results In areas of PCBM reconstruction, cancellous CT radiodensity values were significantly high immediately after the surgery, and subsequently the values became stable. Cortical thickness was significantly increased, but did not reach that of native bone. Implant success rates were statistically not different (P = 0.783) between the native bone (91.3%), the partially grafted bone (95.2%), and the PCBM reconstructed bone (93.3%). Conclusion Implants in pure grafted bone are mainly supported by cancellous bone, because cortical thickness remained thin for a long period of time.

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“…Watanabe et al (2017) reported that the bone scan index of the jaw was significantly higher in patients who developed ONJ than in those who did not, 3 months before the diagnosis of ONJ, underlining its value as a new prognostic index. More advanced imaging procedures like computed tomography (which can evaluate the radiodensity of necrotic bone) (Hamada, Matsuo, Koizumi, Satomi, & Chikazu, 2014), and cone beam computed tomography, are considered superior to established panoramic radiography, and represent a potential additional tool to assist surgical management of ONJ (Guggenberger et al, 2014;Kammerer et al, 2016). More advanced imaging procedures like computed tomography (which can evaluate the radiodensity of necrotic bone) (Hamada, Matsuo, Koizumi, Satomi, & Chikazu, 2014), and cone beam computed tomography, are considered superior to established panoramic radiography, and represent a potential additional tool to assist surgical management of ONJ (Guggenberger et al, 2014;Kammerer et al, 2016).…”

Section: Predictive and Prognostic Factorsmentioning

confidence: 99%

Antiresorptive treatment-associated ONJ

Eleutherakis‐Papaiakovou

Bamias

2017

Eur J Cancer Care

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Osteonecrosis of the jaw (ONJ) is a severe complication of therapy with antiresorptive agents (e.g. bisphosphonates and denosumab), which are used to manage bone metastases from cancer, to reduce the incidence of skeletal-related events. Available data indicate that 0-27, 5% of patients exposed to antiresorptive agents may develop ONJ, depending on the number of infusions and the duration of therapy. Besides antiresorptive therapy, a number of risk factors for osteonecrosis have been identified. Oral surgical procedures, tooth extractions and infection to the jawbones are considered the main risk factors for developing ONJ, when receiving antiresorptive therapy. However, a growing number of patients develop ONJ without apparent risk factors, raising concern for other predisposing factors. Jaw bone necrosis may be irreversible, resulting in a chronic disease with negative impact on the quality of patients' lives. The role of risk reduction strategies like meticulous dental screening and optimal oral hygiene is fundamental for preventing development of ONJ. ONJ is usually treated conservatively to relieve the symptoms and manage jaw bone necrosis. In certain cases, surgical intervention is required. Future research should emphasize individual predisposition to ONJ, more effective preventive measures and more efficient therapeutic procedures.

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A simple evaluation method for early detection of bisphosphonate-related osteonecrosis of the mandible using computed tomography

Cited by 46 publications

References 38 publications

Bisphosphonate-related osteonecrosis of the jaw: from the sine qua non condition of bone exposure to a non-exposed BRONJ entity

Bisphosphonate-related osteonecrosis of the jaw: from the sine qua non condition of bone exposure to a non-exposed BRONJ entity

Long‐term structural changes and outcomes of implants in particulate cellular bone and marrow reconstructed jawbone

Antiresorptive treatment-associated ONJ

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