A simple improved desolvation method for the rapid preparation of albumin nanoparticles

Jahanban-Esfahlan, Ali; Dastmalchi, Siavoush; Davaran, Soodabeh

doi:10.1016/j.ijbiomac.2016.05.032

Cited by 189 publications

(100 citation statements)

References 19 publications

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“…Ly NPs were prepared by desolvation (Jahanban‐Esfahlan, Dastmalchi, & Davaran, ). Ly was dissolved in purified water with gentle magnetic stirring for 2 hr at room temperature at the concentration of 1.0 mg/mL.…”

Section: Methodsmentioning

confidence: 99%

Curcumin encapsulation and protection based on lysozyme nanoparticles

Cui

Zhou

Huang

et al. 2019

Food Science & Nutrition

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Curcumin possesses antioxidant, anti‐inflammatory, and other properties. However, this compound exhibits low bioavailability because of its poor solubility and stability. In this paper, lysozyme nanoparticles were fabricated through solvent evaporation, and then, the solubilization and protection capability of curcumin were investigated. Lysozyme nanoparticles were characterized by dynamic light scattering technique, atomic force microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. The load capacity and stability in thermal environment were further explored. Results showed that the lysozyme nanoparticle displayed a spherical structure (127.9 ± 2.12 nm) with favorable distribution. The solubility of curcumin can increase to 22 μg/mL. After encapsulation by lysozyme nanoparticles, the retentive curcumin can reach up to 67.9% and 30.25% at 25°C and 50°C, respectively, significantly higher than that of free curcumin. Meanwhile, experiments on DPPH free radicals indicated the curcumin loaded by lysozyme nanoparticle possessed higher free radical scavenging activity than that of free curcumin with same treatments. The results confirmed that lysozyme nanoparticles exhibit potential applications in solubilizing and protecting the environment‐sensitive hydrophobic functional components.

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Section: Methodsmentioning

confidence: 99%

Curcumin encapsulation and protection based on lysozyme nanoparticles

Cui

Zhou

Huang

et al. 2019

Food Science & Nutrition

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“…The surface of IONPs was modified with natural AAs using a simple, green and one‐pot in situ approach. During the synthesis of the nanoparticles, the rate of addition of ammonium solution could be controlled by a modified homemade apparatus which has been reported previously (Figure ) . With this device we can control the nucleation and growth of the nanocrystals and can effectively achieve iron oxide nanocrystals with narrow size distribution.…”

Section: Resultsmentioning

confidence: 99%

“…During the synthesis of the nanoparticles, the rate of addition of ammonium solution could be controlled by a modified homemade apparatus which has been reported previously (Figure 1). [27] With this device we can control the nucleation and growth of the nanocrystals and can effectively achieve iron oxide nanocrystals with narrow size distribution. Figure 2 shows the TEM images and size distributions measured from the TEM images of AA-coated IONPs.…”

Section: Characterization Of Size and Morphologymentioning

confidence: 99%

Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation

Nosrati

Salehiabar

Attari

et al. 2017

Applied Organom Chemis

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We report the synthesis of iron oxide magnetic nanoparticles (IONPs) coated with various natural amino acids (AAs) using a one‐pot reaction in an aqueous medium. Several AAs, which contained hydrophilic and hydrophobic groups, were selected to study their effects on size, morphology and toxicity of IONPs. Functionalized IONPs were characterized using X‐ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and scanning and transmission electron microscopies. Furthermore, vibrating sample magnetometry analysis shows these nanoparticles have excellent magnetic properties. Cellular toxicity of IONPs was also investigated on HFF2 cell lines. The AA‐coated IONPs are non‐toxic and biocompatible. Natural AA‐coated IONPs show a potential for their development in in vitro and in vivo biomedical fields due to their non‐toxicity, good ζ‐potential and related small size and narrow size distribution.

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“…Numerous reports are available on synthesis and process optimization of bovine and human serum albumin nanoparticles using the desolvation process [45][46][47][48]. The procedure adopted for the production of nanoparticles involves the use of tubing pumps and other designed apparatus for controlled addition of desolvating agent [49]. Furthermore the particle size around 100-150nm is obtained in acidic and alkaline condition.…”

Section: Introductionmentioning

confidence: 99%

A simple and reproducible method for production of protein nanoparticles at biological pH using egg white

2019

Biointerface Res Appl Chem

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Protein nanoparticles have been found to be of great interest as a carrier in a drug delivery system due to its biodegradability and non toxic nature. The purpose of the present investigation is to establish a simple and fast method for the preparation of stable egg white protein (EWP) nanoparticles. Desolvation process was adopted and the resulting nanoparticles were stabilized by a crosslinker, glutaraldehyde. To get the suitable and stable nanoparticles several process parameters such as pH, agitation speed, concentration of egg white, rate of addition of desolvating agent, gluteraldehyde concentration and addition of salt and buffer were examined. The minimum size of 112nm has been obtained at pH 9.0 when ethanol addition rate was 1ml/min at an agitation speed of 550 rpm. The size of nanoparticles is affected largely by pH of egg white while it is not significantly affected by the agitation speed and concentration of egg white and crosslinker. The SEM monochrome image of eggwhite nanoparticles displays the spherical shape with around 100nm size.

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A simple improved desolvation method for the rapid preparation of albumin nanoparticles

Cited by 189 publications

References 19 publications

Curcumin encapsulation and protection based on lysozyme nanoparticles

Curcumin encapsulation and protection based on lysozyme nanoparticles

Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation

A simple and reproducible method for production of protein nanoparticles at biological pH using egg white

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