This chapter emphasizes on the static and dynamic characteristics of multi-story building subjected to uniformly distributed and wind load. First-order shear deformation theory is used to formulate governing equations based on the finite element method. The multi-story building is considered as a vertical cantilever beam/plate and modeled using nine-node degenerated shell element. Fictitious membrane and shear stresses are eliminated by considering Mixed Interpolation Tonsorial Component (MITC) technique. Here, the static and dynamic characteristics of multi-story buildings have been investigated take into account as a vertical cantilever plate subjected to UDL, triangular load (wind load) and combination of both. In this chapter authors demonstrated the deformation shapes, longitudinal stress and in-plane shear stress and principle strains in various loading conditions of vertical cantilever flat panel. Moreover, investigated the dynamic characteristics of multi-story buildings considering as a vertical cantilever plates and governing equations of motion are derived by employing Hamilton’s principle. Moreover, nonlinear transient response of high-rise structures has been studied here by employing the energy and momentum conservation implicit time integration scheme. The structural analysis of tall buildings has been carried out here through commercial software ANSYS. Matrix amplitude method is employed to investigate the large-amplitude flexural vibration responses of flat panels. Also, plotted the fast Fourier transform and phase portraits for first three bending modes.