A simple method for calculating the probability of excluding paternity with any number of codominant alleles

Ohno, Youkichi; Sebetan, Ismail M.; Akaishi, Suguru

doi:10.1016/0379-0738(82)90155-4

Cited by 112 publications

(47 citation statements)

References 4 publications

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“…Expected and observed heterozygosity values, Hardy Weinberg equilibrium (HWE) and parameters of forensic interest were calculated for each marker in both populations: PD (power of discrimination and exclusion, Jones, 1972) and CE (a priori chance of exclusion, Ohno et al 1982). Due to the fact that the sample size for some islands was small, no interisland analysis of molecular variance was performed.…”

Section: Discussionmentioning

confidence: 99%

Genetic Differentiation of the Cabo Verde Archipelago Population Analysed by STR Polymorphisms

Fernandes

Velosa

Jesús

et al. 2003

Annals of Human Genetics

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SummaryAllele frequencies for 17 STR loci were analyzed in a sample of unrelated males from the Cabo Verde Archipelago. The samples were gathered in such a way that the origin of the subjects was perfectly identified, and they could be included in one of the leeward or windward groups of islands. This study reveals that there are significant differences between both groups of islands, and between Cabo Verdeans and other populations from sub-Sahara Africa including the Guineans, the most probable source population for Cabo Verdeans. This study confirms mtDNA data and, together with HLA and Y chromosome data already published, shows that the Cabo Verde population is substructured and atypical, diverging substantially from mainland sub-Saharan populations. Overall these differences are most probably due to admixture between sub-Saharan slaves brought into the islands and other settlers of European origin. In the absence of a clear indication of a different ethnic composition of the first sub-Saharan settlers of Cabo Verde, the differentiation exhibited in both groups of islands can be most probably be attributed to genetic drift.

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Section: Discussionmentioning

confidence: 99%

Genetic Differentiation of the Cabo Verde Archipelago Population Analysed by STR Polymorphisms

Fernandes

Velosa

Jesús

et al. 2003

Annals of Human Genetics

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“…An unbiased estimate of heterozygosity was computed according to Nei [12], discrimination power according to Jones [13] and chance of exclusion according to Ohno et al [14]. To test linkage disequilibrium it was used an exact test proposed on the Genepop program [15] and comparison of population data was carried out using an exact test with the STRUC program [16].…”

Section: Methodsmentioning

confidence: 99%

Population distribution of six PCR-amplified loci in Madeira Archipelago (Portugal)

Côrte-Real¹,

Souto²,

Anjos³

et al. 1999

Forensic Science International

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“…P E calculation was first described by Wiener et al (1930) for biallelic loci, and was subsequently extended to loci with any number of codominant alleles (Jamieson, 1965;Selvin, 1980;Ohno et al, 1982;Chakraborty et al, 1988;Dodds et al, 1996;Weir 1996, p 209;Jamieson and Taylor, 1997) and to dominant loci (Chakraborty et al, 1974;Gerber et al, 2000). The probability of excluding a relative of (rather than a random individual unrelated to) the true father from paternity when the maternal genotype is known was also derived (Salmon and Brocteur, 1978;Thompson and Meagher, 1987;Double et al, 1997;Fung et al, 2002;Hu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Parentage and sibship exclusions: higher statistical power with more family members

Wang

2007

Heredity

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Parentage exclusion probabilities are now routinely calculated in genetic marker-assisted parentage analyses to indicate the statistical power of the analyses achievable for a given set of markers, and to measure the informativeness of a set of markers for parentage inference. Previous formulas invariably assume that parentage is to be sought for a single offspring, while in practice multiple full siblings might be sampled (for example, seeds, eggs or young from a pair of monogamous parents) and their father, mother or both are to be assigned among a number of candidates. In this study, I derive formulas for parentage exclusion probabilities for an arbitrary number (n) of fullsibs, which reduce to previous equations for the special case of n ¼ 1. I also derive sibship exclusion probabilities, and investigate the power of differentiating half-sib, avuncular and grandparent-grandoffspring relationships using unlinked autosomal markers among different numbers of tested individuals. Applications of the formulas are demonstrated using both theoretical and empirical data sets of allele frequencies. The results from the study highlight the conclusion that the power of genealogical relationship inferences can be enhanced enormously by analysing multiple individuals for a given set of markers. The equations derived in this study allow more accurate determination of marker information and of the power of a parentage/sibship analysis. In addition, they can be used to guide experimental designs of parentage analyses in selecting markers and determining the number of offspring to be sampled and genotyped.

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A simple method for calculating the probability of excluding paternity with any number of codominant alleles

Cited by 112 publications

References 4 publications

Genetic Differentiation of the Cabo Verde Archipelago Population Analysed by STR Polymorphisms

Genetic Differentiation of the Cabo Verde Archipelago Population Analysed by STR Polymorphisms

Population distribution of six PCR-amplified loci in Madeira Archipelago (Portugal)

Parentage and sibship exclusions: higher statistical power with more family members

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