In continuous chemical processes, disturbances in the process conditions can propagate widely and cause secondary upsets in remote locations. The aim of this paper is to apply some recent data-driven methods for detection and diagnosis of process disturbances using historical process data that have been proving successful in a range of applications. An industrial case study is presented in which a plant-wide control system disturbance caused by the presence of a recycle was successfully located and then verified by further plant testing.