A Simple Method for Screening Antihyperlipidemic Agents

Hasimun, Patonah; Sukandar, E. Y.; Adnyana, I Ketut; Tjahjono, Daryono Hadi

doi:10.3923/ijp.2011.74.78

Cited by 11 publications

(11 citation statements)

References 7 publications

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“…The experiment was performed according to the method previously described by Hasimun et al [27]. 30 mice were randomly categorised into five groups.…”

Section: Evaluation Of the Antihyperlipidemic Effectmentioning

confidence: 99%

Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle‐enriched probiotics on the lipid profiles of mice

Mirjani

Faramarzi

Sharifzadeh

et al. 2015

IET nanobiotechnol.

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Hypercholesterolemia is an important risk factor contributing to atherosclerosis and coronary heart disease. Lactic acid bacteria have attracted much attention regarding their promising effect on serum cholesterol levels. Tellurium (Te) is a rare element that has also gained considerable interest for its biological effects. There have been some recent in vivo reports on the reduction effect of Te on cholesterol content. In this study, Lactobacillus plantarum PTCC 1058 was employed for the intracellular biosynthesis of Te NPs. The UV-visible spectrum of purified NPs showed a peak at 214 nm related to the surface plasmon resonance of the Te NPs. Transmission electron microscopy showed that spherical nanoparticles without aggregation had the average size of 45.7 nm as determined by the laser scattering method. The energy dispersive X-ray pattern confirmed the presence of Te atoms without any impurities. A significant reduction was observed in group which received L. plantarum with or without Te NPs during propylthiouracil and cholesterol diet in compare with the control group which received just propylthiouracil and cholesterol. The levels of triglycerides also remarkably decrease (p<0.05) in mice given L. plantarum with intracellular Te NPs.

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“…The experiment was performed according to the method previously described by Hasimun et al [27]. 30 mice were randomly categorised into five groups.…”

Section: Evaluation Of the Antihyperlipidemic Effectmentioning

confidence: 99%

Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle‐enriched probiotics on the lipid profiles of mice

Mirjani

Faramarzi

Sharifzadeh

et al. 2015

IET nanobiotechnol.

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“…In addition PTU, antithyroid, can inhibit the formation of thyroid hormones. Then, the thyroid inhibition will increase the blood cholesterol concentration through endogenous cholesterol biosynthesis [ 11 ]…”

Section: Resultsmentioning

confidence: 99%

Cholesterol-Lowering Effect of Beta Glucan Extracted from Saccharomyces cerevisiae in Rats

Kusmiati

2016

Sci. Pharm.

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Glucans are present in fungi, plants, algae, and bacteria. β-Glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. Glucans are glucose polymers with an α- or β-type glycosidic chain. The role of (1→3)-β-D-glucan is in the maintenance of yeast cell wall shape and rigidity. Studies reveal that soluble glucans can lower total cholesterol and LDL levels in patients with hypercholesterolemia. The important benefit of β-glucan is to improve the immune system and to decrease cholesterol levels in the blood. Several studies have reported the benefits of β-glucan as: antiseptic, antioxidant, anti-aging, immune system activators, protection against radiation, anti-inflammatory, anti-diabetic, anti-cholesterol etc. In this research S. cerevisiae was cultured in yeast extract–peptone–glucose (YPG) broth medium to produce beta-glucan. Cells were harvested at the stationary phase, washed, and disrupted by means of sonication method. The obtained cell walls were used to prepare alkali-soluble β-glucan (glucan-S1). In this regard, 2% sodium hydroxide (NaOH) and 3% acetic acid were used in alkaline–acid extraction, respectively.Potential use of beta-glucan extract as an anticholesterol agent was tested using Sprague dawley strain rats. The experiments were divided into eight groups with four replicates: Group I (normal control), group II (fed with cholesterol without beta-glucan), group III (fed with cholesterol + atorvastatin), group IV (fed with cholesterol + β-glucan standard), group V–VIII (fed of cholesterol + β-glucan of S. cerevisiae with each dose of 10, 20, 30, and 40 mg / BW. Rats were fed with cholesterol for 14 days, except for group I. Analysis of blood was carried out to determine total cholesterol, triglycerides, and malondialdehyde.The results showed that beta-glucan crude obtained from S. cerevisiae cultures was 6.890g.L−1. Βeta-glucan extract of S. cerevisiae can reduce total cholesterol approaching normal values at doses of 10 mg of 32.79 % (blood plasma) and 33.71 % (in the liver). The extract was capable of reducing triglyceride levels in a dose of 10 mg of beta-glucan 64.43 % (blood plasma) and at a dose 30 mg of beta-glucan 19.45 % (liver). Beta-glucan treatment at a dose of 40 mg can reduce MDA levels of 45.22 % (blood plasma) and 42.64 % (liver).

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“…The goals of this research were to evaluate the effect of binahong leaves fractions in cholesterol in male Wistar rats 200-250 g. The modified method [6] from previous research [19] was used in the present research. On the week 0, 3 rd , 7 th , and 11 th , the rats were induced by pure cholesterol orally for 7 days with high cholesterol feed.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing in endothelial nitric oxide (NO) synthase by LDL could increase NO and can cause damage endothelial cell [18]. Research by Fungwe [19] found that addition of cholesterol in diet is contributed to increase total cholesterol in plasma and LDL plasma.…”

Section: Based Onmentioning

confidence: 99%

Anredera Cordifolia Leaves Fraction as an Anti-Hyperlipidemia

Lestari

2016

Asian J Pharm Clin Res

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Objective: The objective of this research was to evaluate reduction of blood cholesterol level by fraction extracts of binahong (Anredera cordifolia) on male Wistar rats. Methods: The rats were given high fat food every day for 3 months and pure cholesterol on week 0, 3, 7 and 11. After that each binahong fraction (n-hexane fraction, ethyl acetate fraction and water fraction) with doses of 50 mg/kg bw, 100 mg/kg bw, 200 mg/kg bw were given orally for 3 weeks and observed for lipid profile on day 21. Results: The result showed that n-hexane, ethyl acetate and water fractions of binahong leaves decreased total cholesterol, triglyceride and LDL level, and did not influence the HDL level. Meanwhile statin decreased total cholesterol, triglyceride and LDL level, and increased HDL level. Conclusion: Ethyl acetate fraction of binahong leaves significantly reduced total cholesterol level, triglycerides, LDL level compared to negative control group (p< 0.05) and had no influence in HDL level. Keywords: Atherosclerosis, Anredera cordifolia, cholesterol

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A Simple Method for Screening Antihyperlipidemic Agents

Cited by 11 publications

References 7 publications

Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle‐enriched probiotics on the lipid profiles of mice

Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle‐enriched probiotics on the lipid profiles of mice

Cholesterol-Lowering Effect of Beta Glucan Extracted from Saccharomyces cerevisiae in Rats

Anredera Cordifolia Leaves Fraction as an Anti-Hyperlipidemia

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