A simple method for simultaneous determination of organophosphate esters and their diester metabolites in dairy products and human milk by using solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry

Chen, Xuelei; Zhang, Nan; Li, Liping; Zhao, Rong; Chen, Ning; Fan, Suhua; Shi, Zhixiong

doi:10.1007/s00216-022-04079-3

Cited by 4 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A detailed procedure is described in the Supporting Information and our previous studies. 14,25,26 Quality Assurance and Quality Control (QC). To reduce background contamination, the used plasticware (e.g., PP tubes, centrifuge tube filters, and so on) was prewashed with hexane and methanol, and glass bottles and tubes were baked in a muffle furnace at 400 °C for 6 h before use.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Organophosphate Esters in Raw Cow Milk and Cow’s Drinking Water and Feed from China: Occurrence, Regional Distribution, and Dietary Exposure Assessment

Tang,

Zhou,

Wang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Organophosphate esters (OPEs) have been widely produced and used, while little is known about their occurrence in the food chain and potential sources. In this study, raw cow milk, cow drinking water, and feed were collected from pastures across China, and OPEs were tested to explore the occurrence and transmission of OPEs in the food chain and to further assess daily OPE intakes for cows and humans via certain food consumption. The median level of ∑OPEs (sum of 15 OPEs) in raw milk was 2140 pg/mL, and tris(1-chloro-2-propyl) phosphate (TCIPP) was the most abundant OPE. Levels of OPEs in water were lower than those in raw milk except for triethyl phosphate (TEP), while levels of most OPEs in feed were significantly higher than those in raw milk (adjusted by dry weight). The estimated dietary intake of OPEs via feed for cows was 2530 ng/kg bw/day, which was much higher than that via water (742 ng/kg bw/day), indicating that feed was a more critical exposure source. For liquid milk consumers, the high-exposure (95th) estimated daily intakes (EDIs) of ∑ 15 OPE were 20 and 7.11 ng/kg bw/day for 3−17 years and adults, respectively, and it is obvious that cows had much heavier OPE intake. Finally, the calculated hazard indexes (HIs) suggested that the intake of OPEs via cow milk consumption would not pose significant health risks to the Chinese population.

show abstract

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…More details of different samples and LODs of the tested OPEs are given in our previous study. 14,25,26 Data Analysis. SPSS 26.0 and GraphPad Prism 9.5.0 were used for data calculation and statistical analysis.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%