A Simple Method for the Determination of Gold in Scrum, Blood, and Urine by Atomic Absorption Spectroscopy

Harth, Manfred; Haines, D. S. M.; Bondy, Donald C.

doi:10.1093/ajcp/59.3.423

Cited by 14 publications

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“…A 2 cc sample of the homogenate was then pipetted off and weighed, and the gold concentration in it measured by the same method as the one used for serum and urine. 9 The amount of gold in the whole fecal sample could then be calculated.…”

Section: Methodsmentioning

confidence: 99%

Serum gold levels during chrysotherapy with relation to urinary and fecal excretion

Harth

1974

Clin Pharma and Therapeutics

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The decline of gold in serum and its excretion in urine and feces were studied in the first week following an iniection of sodium aurothiomalate in 10 patients with rheumatoid arthritis. Changes in the renal clearance of gold were also observed over a period of 25 weeks in 13 patients on chrysotherapy. The urinary excretion of gold in the first 24 hours was higher than in the second 24 hours, whereas fecal excretion of gold was greater in the second than in the first clay. The serum gold levels showed a biphasic decline with a rapid early phase and a slow late phase. The latter was assumed to represent the excretion of gold in urine and possibly in feces. The difference over 24 hours between gold levels declining along the slow phase was multiplied by the estimated plasma volume for each patient to give an expected excretion value. These calculated values correlated substantially with the observed urinary excretion values in both the first and second 24 hour periods. There was a gradual increase of renal clearance of gold over a period of 25 weeks in 13 patients. These results suggest that the slow phase of decline of gold may be due to excretion and the rapid phase to tissue absorption. The increase in renal clearance of gold may be due to increased excretion of gold from deposits in body tissue.

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Section: Methodsmentioning

confidence: 99%

Serum gold levels during chrysotherapy with relation to urinary and fecal excretion

Harth

1974

Clin Pharma and Therapeutics

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“…We have recently documented an inverse relationship between the number of capillary loops (scored quantitatively in 5 mm of the distal row of capillaries) and the number of organs involved, in patients with secondary Raynaud's phenomenon ( scleroderma, CREST syndrome [calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias], and mixed connective tissue disease) (5).…”

Section: Nailfold Capillary Abnormalities and Organ Involvement In Scmentioning

confidence: 99%

“…Au(1) binds to DP in a linear manner, forming an ordinary coordination bond without a chelate ring (4). Since auranofin contains Au(1) ( 5 ) , as do all the antiarthritic gold compounds currently available (3), DP cannot form a chelate ring with any of these compounds.…”

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confidence: 99%

“…Peritoneal dialysis was started and effectively lowered BUN and serum creatinine levels (63.0 mg'dl and 2.8 mg/dl, respectively). Serum and dialysate gold levels were assayed using a modification of previously described methods, improving sensitivity to as low as 1.0 pg% (5). In 2 separate clearance trials performed 20 days apart, dialysate gold levels were 1 .…”

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confidence: 99%

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Poor clearance of gold using peritoneal dialysis for the treatment of gold toxicity

Garland

Sheth

Wortmann

1986

Arthritis & Rheumatism

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Rapid Determination of Gold in Whole Blood of Arthritis Patients Using Flameless Atomic Absorption Spectrophotometry

Barrett

DeFries²,

Henderson

1978

Journal of Pharmaceutical Sciences

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A Simple Method for the Determination of Gold in Scrum, Blood, and Urine by Atomic Absorption Spectroscopy

Cited by 14 publications

References 0 publications

Serum gold levels during chrysotherapy with relation to urinary and fecal excretion

Serum gold levels during chrysotherapy with relation to urinary and fecal excretion

Poor clearance of gold using peritoneal dialysis for the treatment of gold toxicity

Rapid Determination of Gold in Whole Blood of Arthritis Patients Using Flameless Atomic Absorption Spectrophotometry

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