1953
DOI: 10.1136/jcp.6.1.9
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A Simple Method of Studying the Generation of Thrombin in Recalcified Plasma: Application in the Investigation of Haemophilia

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Cited by 146 publications
(78 citation statements)
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“…The thrombin generation time (TGT) was originally described by Macfarlane and Biggs [7] for whole blood and by Pitney and Dacy [8] for plasma. Since then, a vast number of variants have been published, all differing in detail from one another.…”
Section: Thrombin Generation Test and Thromboelastographymentioning
confidence: 99%
“…The thrombin generation time (TGT) was originally described by Macfarlane and Biggs [7] for whole blood and by Pitney and Dacy [8] for plasma. Since then, a vast number of variants have been published, all differing in detail from one another.…”
Section: Thrombin Generation Test and Thromboelastographymentioning
confidence: 99%
“…Thrombin Generation Test-This assay is a modification of that carried out by Pitney and Dacie (22). Normal platelet-poor plasma was used as substrate.…”
Section: Screening the Phage Library With Mab Esh8 -The Different M13mentioning
confidence: 99%
“…These tests have their natural end point at a time when only 3-5 % of thrombin has been formed. Although it was developed half a century ago [1,2], it is only during the last one and a half decade that the thrombin generation test has attracted increasing attention. It appears that this test may replace coagulation based tests in many cases in the future [3,4], more so as computer aided models of the events leading to coagulation have been developed and been shown to correlate well with biochemical observations [5,6].…”
Section: Introductionmentioning
confidence: 99%