A simple method to achieve high doxorubicin loading in biodegradable polymersomes

Sanson, Charles; Schatz, Christophe; Meins, Jean-François Le; Soum, Alain; Thévenot, Julie; Garanger, Élisabeth; Lecommandoux, Sébastien

doi:10.1016/j.jconrel.2010.07.123

Cited by 324 publications

(265 citation statements)

References 51 publications

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“…In general, polymeric micelle-based carriers can achieve substantial drug-loading levels of approximately 15%-20%. 28 In the PGA MWCNT system, drug-loading levels were threefold higher than the COOH MWCNT system and tenfold higher than reported polymeric micelle systems. By contrast, Hep MWCNTs had the lowest drug-loading Figure 6.…”

Section: Drug-loading and Zeta-potential Resultsmentioning

confidence: 80%

Drug-loading capacity and nuclear targeting of multiwalled carbon nanotubes grafted with anionic amphiphilic copolymers

Tsai¹,

Lin²,

Maryani³

et al. 2013

IJN

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In this study, three types of hybrid nanotubes (NTs), ie, oxidized multiwalled carbon NTs (COOH MWCNTs), heparin (Hep)-conjugated MWCNTs (Hep MWCNTs), and diblock copolymer polyglycolic acid (PGA)- co -heparin conjugated to MWCNTs (PGA MWCNTs), were synthesized with improved biocompatibility and drug-loading capacity. Hydrophilic Hep substituents on MWCNTs improved biocompatibility and acted as nucleus-sensitive segments on the CNT carrier, whereas the addition of PGA enhanced drug-loading capacity. In the PGA MWCNT system, the amphiphilic copolymer (PGA-Hep) formed micelles on the side walls of CNTs, as confirmed by electron microscopy. The PGA system encapsulated the hydrophobic drug with high efficiency compared to the COOH MWCNT and Hep MWCNT systems. This is because the drug was loaded onto the PGA MWCNTs through hydrophobic forces and onto the CNTs by π–π stacking interactions. Additionally, most of the current drug-carrier designs that target cancer cells release the drug in the lysosome or cytoplasm. However, nuclear-targeted drug release is expected to kill cancer cells more directly and efficiently. In our study, PGA MWCNT carriers effectively delivered the active anticancer drug doxorubicin into targeted nuclei. This study may provide an effective strategy for the development of carbon-based drug carriers for nuclear-targeted drug delivery.

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Section: Drug-loading and Zeta-potential Resultsmentioning

confidence: 80%

Drug-loading capacity and nuclear targeting of multiwalled carbon nanotubes grafted with anionic amphiphilic copolymers

Tsai¹,

Lin²,

Maryani³

et al. 2013

IJN

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“…Very recently, by using polymersomes made from the self-assembly of a temperature-responsive poly(trimethylene carbonate)-block-poly(L-glutamic acid) copolymer, our group demonstrated a temperature-increased permeability and mobility inside the membrane which favor the Fickian diffusion of entrapped doxorubicin molecules through the membrane [86].…”

Section: Stimuli-responsive Vesiclesmentioning

confidence: 99%

Recent trends in the tuning of polymersomes’ membrane properties

2011

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Abstract. "Polymersomes" are vesicular structures made from the self-assembly of block copolymers. Such structures present outstanding interest for different applications such as micro-or nano-reactor, drug release or can simply be used as tool for understanding basic biological mechanisms. The use of polymersomes in such applications is strongly related to the way their membrane properties are controlled and tuned either by a precise molecular design of the constituting block or by addition of specific components inside the membrane (formulation approaches). Typical membrane properties of polymersomes obtained from the self-assembly of "coil coil" block copolymer since the end of the nineties will be first briefly reviewed and compared to those of their lipidic analogues, named liposomes. Therefore the different approaches able to modulate their permeability, mechanical properties or ability to release loaded drugs, using macromolecular engineering or formulations, are detailed. To conclude, the most recent advances to modulate the polymersomes' properties and systems that appear very promising especially for biomedical application or for the development of complex and bio-mimetic structures are presented.

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“…DOX has a pKa of 8.3 and is positively charged at a pH of 7.4. Therefore, DOX is attracted to the negatively charged nanocarriers without additional surface functionalization [13]. The loaded DOX was subsequently released into PBS with different pH values.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Europium-doped Fluorapatite Nanorods and Their Multifunctional Biomedical Applications

Zeng¹,

Sun²,

Wu³

et al. 2017

Preprint

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Europium (Eu)-doped fluorapatite (FA) nanorods have a biocompatibility similar to that of hydroxyapatite (HA) for use as cell imaging biomaterials due to their luminescent property. Here, we discuss the new application of europium-doped fluorapatite (Eu-FA) nanorods as an anticancer drug carrier. The Eu-FA nanorods were prepared by using a hydrothermal method. The morphology, crystal structure, fluorescence and composition were investigated. The specific crystal structure enables the effective loading of drug molecules. Doxorubicin (DOX), which was used as a model anticancer drug, effectively loaded onto the surface of the nanorods. The DOX release was pH dependent and occurred more rapidly at pH 5.5 than pH 7.4. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA exhibits potential for tracking and treating tumors and may be potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs.

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A simple method to achieve high doxorubicin loading in biodegradable polymersomes

Cited by 324 publications

References 51 publications

Drug-loading capacity and nuclear targeting of multiwalled carbon nanotubes grafted with anionic amphiphilic copolymers

Drug-loading capacity and nuclear targeting of multiwalled carbon nanotubes grafted with anionic amphiphilic copolymers

Recent trends in the tuning of polymersomes’ membrane properties

Synthesis of Europium-doped Fluorapatite Nanorods and Their Multifunctional Biomedical Applications

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