A simple method to obtain a swollen PVA gel crosslinked by hydrogen bonds

Otsuka, Emiko; Suzuki, Atsushi

doi:10.1002/app.30546

Cited by 118 publications

(95 citation statements)

References 25 publications

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“…A straightforward method to produce PVA hydrogels was reported by Otsuka et al113 The hydrogels were prepared by pouring a PVA solution into a plastic dish and leaving the sample in a closed space at room temperature for 7 d during which the water content decreased by 20 wt.‐%. This incubation afforded formation of polymer intra‐ and intermolecular hydrogen bonds and the resulting hydrogels remained stable when immersed in water over a time period of 60 d indicating the effectiveness of this type of gelation.…”

Section: Supramolecular Polymer Engineeringmentioning

confidence: 99%

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

Alves

Jensen

Smith

et al. 2011

Macromolecular Bioscience

209

159

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Poly(vinyl alcohol), PVA, and physical hydrogels derived thereof have an excellent safety profile and a successful history of biomedical applications. However, these materials are hardly in the focus of biomedical research, largely due to poor opportunities in nano- and micro-scale design associated with PVA hydrogels in their current form. In this review we aim to demonstrate that with PVA, a (sub)molecular control over polymer chemistry translates into fine-tuned supramolecular association of chains and this, in turn, defines macroscopic properties of the material. This nano- to micro- to macro- translation of control is unique for PVA and can now be accomplished using modern tools of macromolecular design. We believe that this strategy affords functionalized PVA physical hydrogels which meet the demands of modern nanobiotechnology and have a potential to become an indispensable tool in the design of biomaterials.

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Section: Supramolecular Polymer Engineeringmentioning

confidence: 99%

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

Alves

Jensen

Smith

et al. 2011

Macromolecular Bioscience

209

159

View full text Add to dashboard Cite

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“…173, 174 The hydrogels also can be formed by physical crosslinking via methods such as cryogenic gelation and hydrogen bonding, 175–177 and PVA hydrogels formed via these methods have been successfully used for tissue engineering and regenerative medicine applications. 176, 178–180 For instance, Samal et al prepared hybrid hydrogels consisting of PVA, chitosan, and multiwalled carbon nanotubes (MWCNT) by the physical freeze-drying method.…”

Section: Materials For Hydrogel Preparationmentioning

confidence: 99%

Designing degradable hydrogels for orthogonal control of cell microenvironments

2013

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“…They have been widely studied as a constitutive material for biomembranes (15,16), cell encapsulation (17,18), or soft-tissue reconstruction (4,19). In that respect, several methods have been developed to induce the gelation of PVA, using solvent evaporation (20), thermal treatments by freezing-thawing (19), coagulation in poor solvent (15), or salting out (21).…”

Section: Significancementioning

confidence: 99%

Hydrogel films and coatings by swelling-induced gelation

Moreau

Chauvet

François

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Hydrogel films used as membranes or coatings are essential components of devices interfaced with biological systems. Their design is greatly challenged by the need to find mild synthesis and processing conditions that preserve their biocompatibility and the integrity of encapsulated compounds. Here, we report an approach to produce hydrogel films spontaneously in aqueous polymer solutions. This method uses the solvent depletion created at the surface of swelling polymer substrates to induce the gelation of a thin layer of polymer solution. Using a biocompatible polymer that self-assembles at high concentration [poly(vinyl alcohol)], hydrogel films were produced within minutes to hours with thicknesses ranging from tens to hundreds of micrometers. A simple model and numerical simulations of mass transport during swelling capture the experiments and predict how film growth depends on the solution composition, substrate geometry, and swelling properties. The versatility of the approach was verified with a variety of swelling substrates and hydrogel-forming solutions. We also demonstrate the potential of this technique by incorporating other solutes such as inorganic particles to fabricate ceramic-hydrogel coatings for bone anchoring and cells to fabricate cell-laden membranes for cell culture or tissue engineering. H ydrogel films are used in a number of biomedical applications like wound healing (1), drug delivery (1), antiadhesive membranes (2), soft-tissue reconstruction (3, 4), and cell culture (5). The quality of their interactions with biological tissues or entrapped cells is central to the performance of these systems. Although considerable advances have been made in synthesis (6) and processing (7) to tailor these interactions, the toxicity of by-products and the degradation caused by harsh processing conditions remain key issues (8), which can be overcome (9) but are often addressed at the cost of difficult synthesis or multistep processes. There is a great interest for simple, versatile, and in vivo-friendly methods to fabricate and modify hydrogels. We propose a strategy to design hydrogel films in mild conditions. This method could be used to produce freestanding hydrogel membranes or hydrogel coatings to functionalize other hydrogels.Our approach relies on the understanding of transport phenomena occurring near the surface of a polymer network swelling in a polymer solution. As an illustration, let us consider a flat polymer network with thickness H 0 immersed in a solution containing a volume fraction Φ 0 of free polymer chains, as depicted in Fig. 1A. When the solvent of the solution is also a solvent for the network, the network swells in a diffusive process. For early immersion times t, the increase in thickness ΔH is given by the following (10, 11):where H ∞ is the thickness at equilibrium swelling in the polymer solution and D 0 is a diffusivity coefficient depending on the dynamics of the network and of the solution. The systems of interest are those where the chains in solution do not penetrate...

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A simple method to obtain a swollen PVA gel crosslinked by hydrogen bonds

Cited by 118 publications

References 25 publications

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

Designing degradable hydrogels for orthogonal control of cell microenvironments

Hydrogel films and coatings by swelling-induced gelation

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