A Simple Method to Prepare Aqueous Dispersion of Iron Oxide Nanoparticles and Their Biodistribution Study

Ahmad, M.; Rashid, Khalid; Nadeem, Muhammad; Masood, Khalid Bin; Ali, Shahid; Nafees, Muhammad; Gull, Nafisa; Mumtaz-ul-Haq, .; Ibrahim, Nabila M.; Saeed, Muhammad; Qureshy, A.; Aleem, F.A. Abdel; Naseer, Hira; Mehmood, Sajid; Hyder, Syed Waqar

doi:10.1166/jcsb.2012.1021

Cited by 16 publications

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“…Colloidal hybrid particles have attracted considerable attention as solid support of biomolecules for cell separation, biomedical diagnosis, nucleic acid extraction, and drug delivery . Recently, several researchers have focused on the preparation of anisotropic (Janus) colloidal particles with asymmetric geometry in shape and/or in surface chemistry due to their fascinating properties including particular chemical, optical, magnetic, and surface properties.…”

Section: Introductionmentioning

confidence: 99%

Anisotropic janus magnetic polymeric nanoparticles prepared via miniemulsion polymerization

Kaewsaneha

Tangboriboonrat

Polpanich

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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Anisotropic Janus magnetic polymeric nanoparticles are prepared via the miniemulsion polymerization of styrene and acrylic acid monomers in the presence of oleic acid‐coated magnetic nanoparticles (MNPs). The controllable phase separation between the polymer matrix and the encapsulated MNPs is a key success factor to produce Janus morphology. The effects of MNPs, 2,2′‐azobis(2‐isobutyronitrile) and sodium dodecyl sulfate contents, on the morphology, chemical composition and colloidal stability of the prepared Janus hybrid particles are investigated. Besides the determination of polymerization conversion, zeta potential, size analysis, TGA, and TEM are applied for characterization of the anisotropic particles. The results show the stable spherical Janus particles containing MNPs (15 wt % magnetic content) located on one side of each polymer particle. The anisotropic submicron Janus magnetic polymeric particles (250 nm) can be easily separated by an external magnet. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 4779–4785

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Section: Introductionmentioning

confidence: 99%

Anisotropic janus magnetic polymeric nanoparticles prepared via miniemulsion polymerization

Kaewsaneha

Tangboriboonrat

Polpanich

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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“…Particles <4 μm are eliminated by cells of the RES, mainly in the liver (60%–90%) and the spleen (3%–10%). Particles >200 nm are usually filtered by the spleen, 18 the cutoff point of which extends up to 250 nm. Particles up to 100 nm are mainly phagocytosed via liver cells.…”

Section: Discussionmentioning

confidence: 99%

“…Black precipitate of Fe 3 O 4 nanoparticles appeared in the solution instantly with mixing of the alkali. 18 Particles were washed with deionized water thrice and dried in oven at 60°C.…”

Section: Methodsmentioning

confidence: 99%

“…Various surface modifications may result in simultaneous reduction in drug dosage and undesirable side effects to the healthy tissues. 11 , 12 , 18 Better physiochemical properties have been achieved by surface modification of magnetic nanoparticles using various polymers, silica, different surfactant, or various organic compounds. Sufficient amount of drug can be loaded onto the stable surfaced nanoparticles with magnetic core shell structure.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Doxorubicin Anticancer Drug Loading on Different Metal Oxide Nanoparticles

et al. 2015

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Nanomaterials are being vigorously investigated for their use in anticancer drug delivery regimes or as biomarkers agents and are considered to be a candidate to provide a way to combat severe weaknesses of anticancer drug pharmacokinetics, such as their nonspecificity. Because of this weakness, a bigger proportion of the drug-loaded nanomaterials flow toward healthy tissues and result in undesirable side effects. It is very important to evaluate drug loading and release efficiency of various nanomaterials to find out true pharmacokinetics of these drugs.This observational study aims to evaluate various surface functionalized and naked nanomaterials for their drug loading capability and consequently strengthens the Reporting of Observational Studies in Epidemiology (STROBE). We analyzed naked and coated nanoparticles of transition metal oxides for their further loading with doxorubicin, a representative water-soluble anticancer drug.Various uncoated and polyethylene glycol-coated metal oxide nanoparticles were synthesized and loaded with anticancer drug using simple stirring of the nanoparticles in a saturated aqueous solution of the drug. Results showed that surface-coated nanoparticles have higher drug-loading capabilities; however, certain naked metal oxide nanoparticles, such as cobalt oxide nanoparticles, can load a sufficient amount of drug.

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“…presented concise reviews on surface effects in magnetic nanoparticles concerned with biomedical applications and for efficient hyperthermia respectively [ 14 , 16 ]. Previously, authors reported that IONPs without any surface modification can stay in the blood for almost 4 hours and can evade reticulo-endothelial (RES) system [ 17 ]. The only issue with these particles is, without surface modification they are unable to load the sufficient amount of drug [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Properties of Polyvinyl Alcohol and Doxorubicine Loaded Iron Oxide Nanoparticles for Anticancer Drug Delivery Applications

et al. 2016

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The current study emphasizes the synthesis of iron oxide nanoparticles (IONPs) and impact of hydrophilic polymer polyvinyl alcohol (PVA) coating concentration as well as anticancer drug doxorubicin (DOX) loading on saturation magnetization for target drug delivery applications. Iron oxide nanoparticles particles were synthesized by a reformed version of the co-precipitation method. The coating of polyvinyl alcohol along with doxorubicin loading was carried out by the physical immobilization method. X-ray diffraction confirmed the magnetite (Fe3O4) structure of particles that remained unchanged before and after polyvinyl alcohol coating and drug loading. Microstructure and morphological analysis was carried out by transmission electron microscopy revealing the formation of nanoparticles with an average size of 10 nm with slight variation after coating and drug loading. Transmission electron microscopy, energy dispersive, and Fourier transform infrared spectra further confirmed the conjugation of polymer and doxorubicin with iron oxide nanoparticles. The room temperature superparamagnetic behavior of polymer-coated and drug-loaded magnetite nanoparticles were studied by vibrating sample magnetometer. The variation in saturation magnetization after coating evaluated that a sufficient amount of polyvinyl alcohol would be 3 wt. % regarding the externally controlled movement of IONPs in blood under the influence of applied magnetic field for in-vivo target drug delivery.

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A Simple Method to Prepare Aqueous Dispersion of Iron Oxide Nanoparticles and Their Biodistribution Study

Cited by 16 publications

References 0 publications

Anisotropic janus magnetic polymeric nanoparticles prepared via miniemulsion polymerization

Anisotropic janus magnetic polymeric nanoparticles prepared via miniemulsion polymerization

Comparison of Doxorubicin Anticancer Drug Loading on Different Metal Oxide Nanoparticles

Magnetic Properties of Polyvinyl Alcohol and Doxorubicine Loaded Iron Oxide Nanoparticles for Anticancer Drug Delivery Applications

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