A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum

Xiao, Yingying; Xu, Linru; Li, Ping; Tang, Xiao-Chong; Qi, Lian‐Wen

doi:10.1016/j.aca.2017.06.014

Cited by 18 publications

(11 citation statements)

References 35 publications

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“…Compared to that of ITO electrode, MPS electrode can enhance the peak current of Ru(bpy) 3 2+ , due to electrostatic attraction. 26 …”

Section: Resultsmentioning

confidence: 99%

“…We pattern the ITO glass by chemical etching. 25,26 We synthesize MPS on the patterned ITO electrode according to the St€ obersolution growth method. 27 The electrochemical and microscopy characterizations of MPS are carried out as described previously.…”

Section: Preparation Of Mpsmentioning

confidence: 99%

“…† MPS are vertically aligned nanochannels (indicated as white pores, 2-3 nm diameter). Compared to that of ITO electrode, MPS electrode can enhance the peak current of Ru(bpy) 32+ , due to electrostatic attraction 26. To reveal the electrochemical behaviors, cyclic voltammograms (CVs) of Arg, Ru(bpy) 32+ , and Ru(bpy) 3 2+ /Arg are investigated.…”

mentioning

confidence: 99%

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Electrogenerated chemiluminescence of a Ru(bpy)₃²⁺/arginine system: a specific and sensitive detection of acetaminophen

Xiao

Wang

et al. 2022

RSC Adv.

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“…Compared to that of ITO electrode, MPS electrode can enhance the peak current of Ru(bpy) 3 2+ , due to electrostatic attraction. 26 …”

Section: Resultsmentioning

confidence: 99%

Section: Preparation Of Mpsmentioning

confidence: 99%

See 1 more Smart Citation

Electrogenerated chemiluminescence of a Ru(bpy)₃²⁺/arginine system: a specific and sensitive detection of acetaminophen

Xiao

Wang

et al. 2022

RSC Adv.

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“…Owing to the negatively charged nanochannels surface, VMSF can significantly enrich positively charged species and facilitate their mass transport via strong electrostatic interactions ( Zhou et al, 2015 ; Liu et al, 2016 ; Guo et al, 2016 ; Xiao et al, 2017 ). Thus, the enhanced electrochemiluminescence (ECL) of Ru (bpy) 3 2+ on VMSF/APTES/3DG during CV scan was investigated using TPrA as the co-reactant.…”

Section: Resultsmentioning

confidence: 99%

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

et al. 2021

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Three-dimensional (3D) electrochemiluminescence (ECL) platform with high sensitivity and good anti-fouling is highly desirable for direct and sensitive analysis of complex samples. Herein, a novel ECL-sensing platform is demonstrated based on the equipment of vertically ordered mesoporous silica-nanochannel films (VMSF) on monolithic and macroporous 3D graphene (3DG). Through electrografting of 3-aminopropyltriethoxysilane (APTES) onto 3DG as molecular glue, VMSF grown by electrochemically assisted self-assembly (EASA) method fully covers 3DG surface and displays high stability. The developed VMSF/APTES/3DG sensor exhibits highly sensitized ECL response of tris(2,2′-bipyridyl) ruthenium (Ru (bpy)32+) taking advantages of the unique characteristics of 3DG (high active area and conductivity) and VMSF nanochannels (strong electrostatic enrichment). The VMSF/APTES/3DG sensor is applied to sensitively detect an important environmental pollutant (4-chlorophenol, with limit of detection or LOD of 30.3 nM) in term of its quenching effect (ECL signal-off mode) toward ECL of Ru (bpy)32+/tri-n-propylamine (TPrA). The VMSF/APTES/3DG sensor can also sensitively detect the most effective antihistamines chlorpheniramine (with LOD of 430 nM) using ECL signal-on mode because it acts as co-reactant to promote the ECL of Ru (bpy)32+. Combined with the excellent antifouling ability of VMSF, the sensor can also realize the analysis of actual environmental (lake water) and pharmaceutical (pharmacy tablet) samples. The proposed 3D ECL sensor may open new avenues to develop highly sensitive ECL-sensing platform.

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“…The high sensitivity with the linear range of 10 nmol/L to 1 mmol/L was obtained. Moreover, paperbased ECL devices could be used for analysis of organic and inorganic compounds and other substances [90][91][92][93][94][95][96][97][98][99][100][101][102][103] involving various scientific fields such as environment monitoring, biochemical assay, food safety, and so on (as shown in Table 1). Then the paper-based microfluidic system [104] has great application potentials.…”

Section: Eelectrochemiluminescence (Ecl)mentioning

confidence: 99%

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Hou

Guo

et al. 2022

J. Anal. Test.

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Point-of-care testing (POCT), as a portable and user-friendly technology, can obtain accurate test results immediately at the sampling point. Nowadays, microfluidic paper-based analysis devices (μPads) have attracted the eye of the public and accelerated the development of POCT. A variety of detection methods are combined with μPads to realize precise, rapid and sensitive POCT. This article mainly introduced the development of electrochemistry and optical detection methods on μPads for POCT and their applications on disease analysis, environmental monitoring and food control in the past 5 years. Finally, the challenges and future development prospects of μPads for POCT were discussed.

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A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum

Cited by 18 publications

References 35 publications

Electrogenerated chemiluminescence of a Ru(bpy)₃²⁺/arginine system: a specific and sensitive detection of acetaminophen

Electrogenerated chemiluminescence of a Ru(bpy)₃²⁺/arginine system: a specific and sensitive detection of acetaminophen

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

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A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum

Cited by 18 publications

References 35 publications

Electrogenerated chemiluminescence of a Ru(bpy)32+/arginine system: a specific and sensitive detection of acetaminophen

Electrogenerated chemiluminescence of a Ru(bpy)32+/arginine system: a specific and sensitive detection of acetaminophen

Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

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Electrogenerated chemiluminescence of a Ru(bpy)₃²⁺/arginine system: a specific and sensitive detection of acetaminophen

Electrogenerated chemiluminescence of a Ru(bpy)₃²⁺/arginine system: a specific and sensitive detection of acetaminophen