Apparatuses with fluidized bed are widely used in the solid fuel energetic, chemical and other industries. In particular, fluidized bed furnaces play the increasing role for thermo-chemical treatment and burning the solid fuels including bio-fuels. The use of pulsating gas flows is one of the possible ways to intensify the process of gas-particle interaction. However, the efficiency of the way is not always obvious, and new approaches are needed for preliminary estimation of its advantages. The method of mathematical modeling is used to solve the above problem. The model is based on the set of differential equations of a single particle motion in the upstream gas flow with variable with time velocity, and with variable with time particle properties due to this or that thermo-physical or chemical process of gas-particle interaction. The study of influence of the process parameters on its efficiency is done by numerical methods. The model of the effect of oscillations in the gas flow on the efficiency of particle processing in a circulating fluidized bed has been developed. The necessary time for enough particle treatment is compared for different amplitude and frequency of gas flow oscillation. The most considerable gain in time is being reached for the strong dependence of the reaction rate constant on the velocity of flow around the particle. In this case the optimum frequency of oscillations exists that give the maximum gain in time. The growth of the amplitude leads to the monotonic increase of the gain in time, or gives the optimum amplitude. Transition to the pulsating gas flow in a circulating fluidized bed reactor leads to considerable gain in time of particle treatment only in the case of strong dependence of the reaction rate constant on the velocity of flow around the particle. In this case the optimum frequency and amplitude of oscillation exist that gives the maximum gain in time.