A simple ‘no compromise’ method for multiple peptide synthesis

Hyde, Carolyn B.; Johnson, Timothy James; Sheppard, R. C.

doi:10.1007/978-94-011-1470-7_132

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U L T I P L E P E P T I D E S Y N T H E S I S (Mps)1

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1994

1996

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Cited by 2 publications

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“…A very handy system of manual MPS was presented by Sheppard's group 183,184 . The arrays of independent small columns can be connected into series -multicolumns (for the coupling of the same amino acid), or can react in parallel -independently (for the couplings of several different amino acids).…”

Section: U L T I P L E P E P T I D E S Y N T H E S I S (Mps)mentioning

confidence: 99%

Molecular Diversity and Libraries of Structures: Synthesis and Screening

Rinnová

Lebl²

1996

Collect. Czech. Chem. Commun.

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Library, or molecular diversity, approaches are a progressive tool in contemporary investigation of biological interactions and drug discovery. All library approaches include certain degree of rationality and cannot be therefore classified as random or irrational techniques. Reviewed techniques are complementary to so called "rational design"; they can serve either as a tool to generate a lead, or, on the other hand, to optimize a "designed" lead by rapid evaluation of structure-activity relationships. Combinatorial approaches are based on either a random or multiple principle which enables production of large number of diverse molecular structures that can be simultaneously screened and evaluated in a biological assay to find an optimal interacting molecule.

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Section: U L T I P L E P E P T I D E S Y N T H E S I S (Mps)mentioning

confidence: 99%