A Simple Preparation of 1-Substituted Uracils

Naim, Abdul; Shevlin, Philip B.

doi:10.1080/00397919008051586

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…Synthetic methods for 1a and 1b were illustrated in Scheme . Benzoyl-protected 5-iodouracil derivatives with n -butyl and phenyl groups, 4a and 4b , were prepared from 2a 6 and 2b by iodination and protection of NH groups. Coupling reactions between 4a , 4b , and the tributyltin derivative of EDT-TTF (EDT-TTF-SnBu 3 ) produced benzoyl-protected derivatives, 5a and 5b .…”

Section: Resultsmentioning

confidence: 99%

Two-Dimensional Networks of Ethylenedithiotetrathiafulvalene Derivatives with the Hydrogen-Bonded Functionality of Uracil, and Channel Structure of Its Tetracyanoquinodimethane Complex

et al. 2006

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Ethylenedithiotetrathiafulvalene (EDT-TTF) derivatives with N1-butyluracil or N1-phenyluracil moiety were designed and synthesized as new hydrogen-bonded electron-donor molecules with the aim of introducing multiple S...S interactions into the hydrogen-bonded structures composed of the TTF-nucleobase systems. In the crystals of the EDT-TTF derivatives, two-dimensional sheet and layer structures were formed through pi...pi, multiple S...S interactions, and complementary double hydrogen bonds. In the tetracyanoquinodimethane (TCNQ) charge-transfer complex of the EDT-TTF-N1-butyluracil dyad with a segregated column, a layer structure of the electron-donor molecules was constructed through the noncovalent interactions. The n-butyl group of the uracil moiety served to separate the space between the donor layers, resulting in construction of a channel structure. Disordered TCNQ molecules were located in the microporous space of the channel. The TCNQ complex exhibited high electric conductivity (sigmart= 2.1 S cm(-1)) in a single crystal.

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Section: Resultsmentioning

confidence: 99%

Two-Dimensional Networks of Ethylenedithiotetrathiafulvalene Derivatives with the Hydrogen-Bonded Functionality of Uracil, and Channel Structure of Its Tetracyanoquinodimethane Complex

et al. 2006

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“…GSH reacts to generate ROS, which can also be induced by RRx-001 to produce highly active cytotoxic substances such as peroxynitrite (ONOO − ), nitrogen dioxide radicals (•NO 2 ), and other nitrogen oxides, which can lead to DNA methylation and histone acetylation, thereby inducing apoptosis. 52 RRx-001 can also collaborate with P53 to interfere with the pentose phosphate pathway (PPP) and the production of the reducing agent nicotinamide adenine dinucleotide dinucleotide phosphate (NADPH), thereby affecting the synthesis of biological macromolecules and the generation of GSH, thereby disrupting the redox balance and causing a large amount of ROS. It suppresses the growth of tumor cells and promotes apoptosis.…”

Section: N-diazeniumdiolatesmentioning

confidence: 99%

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Huang

Zhang

Luo

et al. 2022

ACS Biomater. Sci. Eng.

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As an important endogenous signaling molecule, nitric oxide (NO) is involved in various physiological and pathological activities in living organisms. It is proved that NO plays a critical role in tumor therapy, while the extremely short half-life and nonspecific distribution of NO greatly limit its further clinical applications. Thus, the past few decades have witnessed the progress made in conquering these shortcomings, including developing innovative NO donors, especially smart and multimodal nanoplatforms. These platforms can precisely control the spatiotemporal distribution of therapeutic agents in the organism, which make big differences in tumor treatment. Here current NO therapeutic mechanisms for cancer, NO donors from small molecules to smart-responsive nanodrug delivery platforms, and NObased combination therapy are comprehensively reviewed, emphasizing outstanding breakthroughs in these fields and hoping to bring new insights into NO-based tumor treatments.

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Phenyl Isocyanate

Troyansky¹

2001

Encyclopedia of Reagents for Organic Synthesis

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A Simple Preparation of 1-Substituted Uracils

Cited by 8 publications

References 10 publications

Two-Dimensional Networks of Ethylenedithiotetrathiafulvalene Derivatives with the Hydrogen-Bonded Functionality of Uracil, and Channel Structure of Its Tetracyanoquinodimethane Complex

Two-Dimensional Networks of Ethylenedithiotetrathiafulvalene Derivatives with the Hydrogen-Bonded Functionality of Uracil, and Channel Structure of Its Tetracyanoquinodimethane Complex

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Phenyl Isocyanate

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