A simple, quick, and cost-effective strategy to fabricate polycaprolactone/silk fibroin nanofiber yarns for biotextile-based tissue scaffold application

Qi, Ye; Wang, Conger; Wang, Qiuyu; Zhou, Fang; Li, Tao; Wang, Bo; Wei-dong, SU; Shang, Dawei; Wu, Shaohua

doi:10.1016/j.eurpolymj.2023.111863

Cited by 55 publications

(25 citation statements)

References 60 publications

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“…In recent years, electrospinning has been widely used in the preparation of tissue engineered scaffolds because of its simplicity, economy, and high controllability of fiber diameters [ 29 ]. During the electrospinning process, several jets are continuously elongated towards the collector, the solvent of the polymeric jets is evaporated quickly, phase separation occurs, the jet solidifies, and nanofibers are formed [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…During the electrospinning process, several jets are continuously elongated towards the collector, the solvent of the polymeric jets is evaporated quickly, phase separation occurs, the jet solidifies, and nanofibers are formed [ 9 ]. More importantly, the electrospun nanofibers exhibit decreased fiber diameter when compared with the microfibers fabricated from some conventional spinning methods, such as melt spinning, wet spinning, dry spinning, and dry-wet spinning, thus resulting in notably increased specific surface area, which is highly needed in several medicinal applications [ 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

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Natural Deep Eutectic Solvent Extraction of Bioactive Pigments from Spirulina platensis and Electrospinning Ability Assessment

Martins

Mouro

Pontes³

et al. 2023

Polymers

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The first ever nanofibers produced by the electrospinning of polyvinyl alcohol (PVA) and Spirulina platensis extracts are presented in this article. Spirulina platensis extracts were obtained by ultrasound-assisted extraction (UAE) using two different solvents: a glucose/glycerol-based natural deep eutectic solvent (NADES) and water. Through spectrophotometry analysis, it was possible to determine the pigment yield of the extractions for both extracts: phycocyanin = 3.79 ± 0.05 mg/g of dry biomass (DB); chlorophylls = 0.24 ± 0.05 mg/g DB; carotenoids = 0.13 ± 0.03 mg/g DB for the NADES/Spirulina extracts, and phycocyanin = 0.001 ± 0.0005 mg/g DB; chlorophylls = 0.10 ± 0.05 mg/g DB; carotenoids = 0.20 ± 0.05 mg/g DB for water/Spirulina extracts. Emulsions were formed by mixing the microalgae extracts in PVA (9%, w/v) at different concentrations: 5, 20, 40, and 50% (v/v). Electrospinning was carried out at the following conditions: 13 cm of distance to collector; 80 kV of applied voltage; and 85 rpm of electrode rotation. After the nanofibers were collected, they were checked under a scanning electron microscope (SEM). ImageJ was also used to determine fiber diameter and frequency. SEM results showed the formation of nanofibers for 5 and 20% (v/v) of NADES/Spirulina extract content in the electrospinning emulsions, presenting diameters of 423.52 ± 142.61 nm and 680.54 ± 271.92 nm, respectively. FTIR confirmed the presence of the NADES extracts in the nanofibers produced. Overall, the nanofibers produced showed promising antioxidant activities, with the NADES/Spirulina- and PVA-based nanofibers displaying the highest antioxidant activity (47%). The highest antimicrobial activity (89.26%) was also obtained by the NADES/Spirulina and PVA nanofibers (20%, v/v). Principal Component Analysis (PCA) revealed positive correlations between both the antioxidant and antimicrobial activities of the electrospun nanofibers, and extract content in the emulsions. Moreover, PCA also indicated positive correlations between the viscosity and conductivity of the emulsions and the diameter of the nanofibers produced.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Natural Deep Eutectic Solvent Extraction of Bioactive Pigments from Spirulina platensis and Electrospinning Ability Assessment

Martins

Mouro

Pontes³

et al. 2023

Polymers

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“…The electrospinning technique is one advanced method that allows the creation of microfibrous scaffolds with desired properties from various materials for use in tissue engineering, treatment of infected wounds, etc. [ 51 , 52 ], and it may be used for the controlled formation of multilayered scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Behaviors and Degradation Properties of Multilayered Polymer Scaffolds: The Phase Space Method for Bile Duct Design and Bioengineering

et al. 2023

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This article reports the electrospinning technique for the manufacturing of multilayered scaffolds for bile duct tissue engineering based on an inner layer of polycaprolactone (PCL) and an outer layer either of a copolymer of D,L-lactide and glycolide (PLGA) or a copolymer of L-lactide and ε-caprolactone (PLCL). A study of the degradation properties of separate polymers showed that flat PCL samples exhibited the highest resistance to hydrolysis in comparison with PLGA and PLCL. Irrespective of the liquid-phase nature, no significant mass loss of PCL samples was found in 140 days of incubation. The PLCL- and PLGA-based flat samples were more prone to hydrolysis within the same period of time, which was confirmed by the increased loss of mass and a significant reduction of weight-average molecular mass. The study of the mechanical properties of developed multi-layered tubular scaffolds revealed that their strength in the longitudinal and transverse directions was comparable with the values measured for a decellularized bile duct. The strength of three-layered scaffolds declined significantly because of the active degradation of the outer layer made of PLGA. The strength of scaffolds with the PLCL outer layer deteriorated much less with time, both in the axial (p-value = 0.0016) and radial (p-value = 0.0022) directions. A novel method for assessment of the physiological relevance of synthetic scaffolds was developed and named the phase space approach for assessment of physiological relevance. Two-dimensional phase space (elongation modulus and tensile strength) was used for the assessment and visualization of the physiological relevance of scaffolds for bile duct bioengineering. In conclusion, the design of scaffolds for the creation of physiologically relevant tissue-engineered bile ducts should be based not only on biodegradation properties but also on the biomechanical time-related behavior of various compositions of polymers and copolymers.

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“…They also resemble the extracellular matrix surrounding cells by their fibrillar structure. Due to their versatility, NFs have evinced great attention as a potential biomaterial in a broad range of biomedicine applications, e.g., tissue engineering [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], biosensors [ 8 , 9 , 10 , 11 ], wound dressings [ 12 , 13 , 14 ] or drug delivery [ 15 ]. Electrospinning is one of the most widely used techniques for generating micro/nanofibers because it is a simple, cost-effective, flexible, and industrially easily up-scalable method.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Adhesion of Electrospun Polycaprolactone Nanofibers to Plasma-Modified Polypropylene Fabric

et al. 2023

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Excellent adhesion of electrospun nanofiber (NF) to textile support is crucial for a broad range of their bioapplications, e.g., wound dressing development. We compared the effect of several low- and atmospheric pressure plasma modifications on the adhesion between two parts of composite—polycaprolactone (PCL) nanofibrous mat (functional part) and polypropylene (PP) spunbond fabric (support). The support fabrics were modified before electrospinning by low-pressure plasma oxygen treatment or amine plasma polymer thin film or treated by atmospheric pressure plasma slit jet (PSJ) in argon or argon/nitrogen. The adhesion was evaluated by tensile test and loop test adapted for thin NF mat measurement and the trends obtained by both tests largely agreed. Although all modifications improved the adhesion significantly (at least twice for PSJ treatments), low-pressure oxygen treatment showed to be the most effective as it strengthened adhesion by a factor of six. The adhesion improvement was ascribed to the synergic effect of high treatment homogeneity with the right ratio of surface functional groups and sufficient wettability. The low-pressure modified fabric also stayed long-term hydrophilic (ten months), even though surfaces usually return to a non-wettable state (hydrophobic recovery). In contrast to XPS, highly surface-sensitive water contact angle measurement proved suitable for monitoring subtle surface changes.

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A simple, quick, and cost-effective strategy to fabricate polycaprolactone/silk fibroin nanofiber yarns for biotextile-based tissue scaffold application

Cited by 55 publications

References 60 publications

Natural Deep Eutectic Solvent Extraction of Bioactive Pigments from Spirulina platensis and Electrospinning Ability Assessment

Natural Deep Eutectic Solvent Extraction of Bioactive Pigments from Spirulina platensis and Electrospinning Ability Assessment

Biomechanical Behaviors and Degradation Properties of Multilayered Polymer Scaffolds: The Phase Space Method for Bile Duct Design and Bioengineering

Enhanced Adhesion of Electrospun Polycaprolactone Nanofibers to Plasma-Modified Polypropylene Fabric

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