A simple, rapid, green and non-destructive 19F time-domain NMR method for directly fluorine determination in powder of mineral supplements for cattle

Babos, Diego Victor; Garcia, Rodrigo Henrique dos Santos; Colnago, Luiz Alberto; Pereira-Filho, Edenir Rodrigues

doi:10.1016/j.microc.2019.104416

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…Sequentially, the mean was normalized from [−1 to 1] for the T 1 curves and from [0 to 1] for the other experiments. Fitting curves for mono and biexponential adjustments were calculated through ExpDec1 and ExpDec2 Origin functions . The linear calibration curve was calculated using the T 1ρ relaxation rate ( R 1ρ = 1/T 1ρ ) and percentage of forms A and C (mass/mass).…”

Section: Experimental Sectionmentioning

confidence: 99%

“…The linear calibration curve was calculated using the T 1ρ relaxation rate ( R 1ρ = 1/T 1ρ ) and percentage of forms A and C (mass/mass). Limit of detection (LOD) was calculated according Babos and co-workers …”

Section: Experimental Sectionmentioning

confidence: 99%

“…Fitting curves for mono and biexponential adjustments were calculated through ExpDec1 and ExpDec2 Origin functions. 32 The linear calibration curve was calculated using the T 1ρ relaxation rate (R 1ρ = 1/T 1ρ ) and percentage of forms A and C (mass/mass). Limit of detection (LOD) was calculated according Babos and co-workers.…”

mentioning

confidence: 99%

“…Limit of detection (LOD) was calculated according Babos and co-workers. 32 High-Field Solid-State 1H NMR Measurements. The static 1 H NMR spectra of forms A and C were obtained using an Avance III, Bruker, at 9.7 T (400 MHz) with the solid-state probe using a mixed Magic Sandwich Echo (mixed MSE) pulse sequence.…”

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confidence: 99%

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NMR Longitudinal Rotating Frame Relaxation Time (T_1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

Almeida,

Garcia,

Ticona

et al. 2024

Anal. Chem.

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Nuclear magnetic resonance (NMR) longitudinal rotating frame relaxation time (T1ρ), rarely used in low-field NMR, can be more effective than conventional T1 and T2 relaxation times to differentiate polymorphic forms of solid pharmaceuticals. This could be attributed to T1ρ sensibility to structural and molecular dynamics that can be enhanced by changing the strength of the oscillating magnetic field (B 1 ) of spinlock pulses. Here, we compared the capacity of T1, T2, and T1ρ to differentiate inactive (A) and active (C) crystalline forms of the World Health Organization essential drug Mebendazole. The results showed that T1 and T2 values of both forms were statistically identical at 0.47 T. Conversely, T1ρ of both forms measured with weak spinlock B 1 fields, ranging from 0.08 to 0.80 mT were statistically different in the same spectrometer. The T1ρ also has the limit of detection to detect the presence of at least 10% of inactive A form in the active C form. Therefore, T1ρ, measured with weak spinlock B 1 fields can be an effective, streamlined, and complementary approach for characterizing not only solid active pharmaceutical ingredients but other solid-state materials as well.

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Section: Experimental Sectionmentioning

confidence: 99%

Section: Experimental Sectionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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NMR Longitudinal Rotating Frame Relaxation Time (T_1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

Almeida,

Garcia,

Ticona

et al. 2024

Anal. Chem.

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Quality control of agricultural products using magnetic resonance sensors

Moraes,

Iwata,

Montrazi

et al. 2025

Rev. bras. eng. agríc. ambient.

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Nuclear magnetic resonance (NMR) is a spectroscopy technique widely used by chemists and physicists to determine the chemical structure of molecules that was adapted to generate imaging, known as nuclear magnetic resonance imaging (MRI), which is widely used in medical diagnosis. The importance of NMR in chemistry, physics, medicine, materials, and agriculture has been recognized with several Nobel Prizes in Physics, 1952, Chemistry, 1991 and 2002, and Medicine in 2003. Therefore, NMR can be applied to obtain: i) imaging of the human body, animal and materials; ii) high-resolution spectra to obtain structural and dynamical information of chemicals, materials etc.; and iii) quantitative and qualitative information of chemical composition of products such as food and agricultural products, using low-resolution relaxometry. High-resolution NMR and MRI have been applied in agri-food products, mostly as a research tool as they typically rely on expensive and bulk instruments, which restrict their uses in routine applications. The NMR sensors that have been more frequently used in agri-food products are based on low-resolution or low-field or time-domain NMR (TD-NMR) instruments. These low-cost instruments have been used for qualitative and quantitative analysis of agri-food products such as intact seeds and grains, intact fruits, meat, oils, and processed foods. In this paper, an overview of the NMR techniques and its main instrumentation aspects are presented, and some applications of TD-NMR and MRI in the non-invasive analysis of food, seeds, and others agricultural products are discussed.

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A simple, rapid, green and non-destructive 19F time-domain NMR method for directly fluorine determination in powder of mineral supplements for cattle

Cited by 2 publications

References 23 publications

NMR Longitudinal Rotating Frame Relaxation Time (T_1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

NMR Longitudinal Rotating Frame Relaxation Time (T_1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

Quality control of agricultural products using magnetic resonance sensors

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A simple, rapid, green and non-destructive 19F time-domain NMR method for directly fluorine determination in powder of mineral supplements for cattle

Cited by 2 publications

References 23 publications

NMR Longitudinal Rotating Frame Relaxation Time (T1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

NMR Longitudinal Rotating Frame Relaxation Time (T1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

Quality control of agricultural products using magnetic resonance sensors

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Product

Resources

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NMR Longitudinal Rotating Frame Relaxation Time (T_1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept

NMR Longitudinal Rotating Frame Relaxation Time (T_1ρ) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical Ingredients: Proof of Concept