A simple recording grip strength device

Cabe, Patrick A.; Tilson, Hugh A.; Mitchell, Clifford L.; Dennis, Ralph

doi:10.1016/0091-3057(78)90131-4

Cited by 67 publications

(38 citation statements)

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“…Each mouse was allowed to grab a bar attached to a force transducer (Model DFX II; Chatillon) as it was pulled by the tail horizontally away from the bar (Cabe et al, 1978). …”

Section: Methodsmentioning

confidence: 99%

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

et al. 2016

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SUMMARY Cachexia is a wasting syndrome associated with elevated basal energy expenditure and loss of adipose and muscle tissues. It accompanies many chronic diseases including renal failure and cancer and is an important risk factor for mortality. Our recent work demonstrated that tumor-derived PTHrP drives adipose tissue browning and cachexia. Here, we show that PTH is involved in stimulating a thermogenic gene program in 5/6 nephrectomized mice that suffer from cachexia. Fat-specific knockout of PTHR blocked adipose browning and wasting. Surprisingly, loss of PTHR in fat tissue also preserved muscle mass and improved muscle strength. Similarly, PTHR knockout mice were resistant to cachexia driven by tumors. Our results demonstrate that PTHrP and PTH mediate wasting through a common mechanism involving PTHR and there exists an unexpected crosstalk mechanism between wasting of fat tissue and skeletal muscle. Targeting the PTH/PTHrP pathway may have therapeutic uses in humans with cachexia.

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“…Each mouse was allowed to grab a bar attached to a force transducer (Model DFX II; Chatillon) as it was pulled by the tail horizontally away from the bar (Cabe et al, 1978). …”

Section: Methodsmentioning

confidence: 99%

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

et al. 2016

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“…Based on their average diet, the HMB dosage was calculated as ~1% CaHMB (Metabolic Technologies Inc., Ames, Iowa, USA), to achieve an ~0.50 g HMB/kg BW/daily dose [20]. Based on previous human studies, and assuming a rodents metabolism are at least 6 times more than humans, we chose a 6 gram metabolic equivalent HMB intervention (the upper limit given to humans in research [23]) and calculated a human-to-rodent conversion to provide an appropriate, and safe dosage for each animal [20]. Daily food consumption of rats was measured every 6th day by weighing the food remaining and subtracting it from the amount that was administered.…”

Section: Methodsmentioning

confidence: 99%

Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats

Wilson

Grant

Lee

et al. 2012

Journal of the International Society of Sports Nutrition

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PurposeTo determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions.MethodsTwelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given HMB for 16 wk. and then sacrificed.ResultsFat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. In addition, fat mass declined (-56%) in the old HMB condition but not the old control condition. Normalized strength declined and maintained respectively in the control and HMB conditions from 44 to 60 wk. and increased (+23%) (p < 0.05) from 86 to 102 wk. in only the HMB condition. Declines occurred in myofiber size in all muscles from 44 to 102 wk. in the control condition(-10 to -15%), but not HMB condition. Atrogin-1 mRNA expression in the SOL and GAS muscles was greater in the 102-wk control condition than all other conditions: SOL (+45%) and GAS (+100%). This elevation was blunted by HMB in the 102 wk. old SOL. There was a condition effect in the SOL for myogenin, which significantly increased (+40%) only in the 102-wk. HMB group relative to the 44-wk. group.ConclusionsHMB may blunt age-related losses of strength and myofiber dimensions, possibly through attenuating the rise in protein breakdown.

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“…In this case, it was removed from the apparatus and immediately evaluated for three parameters: (a) grip or prehension strength: resistance presented by the mice after they are placed on a grid and pulled by the tail (recording the highest figure of three measurements). The reading was carried out by a grip strength meter coupled to the grid (Cabe et al, 1978). (b) motor coordination: longer stay on the rotarod in two attempts of up to 60 s (Marques et al, 2004); (c) locomotor activity: evaluated in photocell motor activity boxes, for 30 min, according to the method described by Mendes et al (2002).…”

Section: Animalsmentioning

confidence: 99%

Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity

Mendes

Tabach

Carlini

2007

Phytotherapy Research

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Baccharis trimera (Asteraceae) and Davilla rugosa (Dilleniaceae) are used popularly as tonics, aphrodisiacs and for stomach ailments, among other uses. Hydroalcohol extracts of the aerial parts of both plants were investigated with regard to their chemical constitution and their pharmacological activity in tests that evaluate adaptogen activity. Alkaloids, flavonoids, saponins, polyphenols/tannins and coumarins were identified in both extracts, while lignans were found only in the extract of Davilla rugosa. This extract presented also a marked antioxidant activity and exerted a moderate antiulcer effect in rats submitted to cold immobilization stress. It did not, however, inhibit the increase in the levels of ACTH and corticosterone induced by stress. Moreover, the Davilla rugosa did not improve the physical performance of mice submitted to forced exercise and the learning time of old rats in the T-maze, neither did it reduce the blood viscosity of the old animals. Conversely, the Baccharis trimera extract only presented a moderate antioxidant activity, without any positive effect on the other tests. These results point to the absence of an adaptogen activity of Baccharis trimera, with some effects that could be related to such an activity as regards the Davilla rugosa.

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A simple recording grip strength device

Cited by 67 publications

References 1 publication

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats

Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity

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