A simple score for early risk stratification in acute heart failure

Xanthopoulos, Andrew; Giamouzis, Grigorios; Tryposkiadis, Konstantinos; Paraskevopoulou, E; Paraskevopoulou, Patrina; Karagiannis, Georgios; Patsilinakos, S; Parissis, John; Farmakis, Dimitrios; Butler, Javed; Skoularigis, John; Triposkiadis, Filippos

doi:10.1016/j.ijcard.2016.12.131

Cited by 22 publications

(17 citation statements)

References 64 publications

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“…It is mainly used for the differential diagnosis of microcytic anemia. Recently, similar with Hcy, RDW was found to be associated with morbidity and mortality in cardiovascular diseases [ 37 ]. A study showed that RDW may be a predictor marker of persistent pulmonary hypertension of the newborn [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width and homocysteine act as independent risk factors for cardiovascular events in newly diagnostic essential hypertension

Gao²,

Wang

et al. 2017

Oncotarget

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Hyperhomocysteinemia and increased red cell distribution width (RDW) are associated with a higher possibility of adverse clinical outcomes of hypertension. The study aims to validate the effect of homocysteine (Hcy) and RDW on cardiovascular events (CVE) and investigate whether RDW is independently associated with serum Hcy in patients with essential hypertension (EH). The study reviewed 804 patients with newly diagnosed EH in our hospital. The clinical characteristics and laboratory results of all subjects were grouped according to the presence/absence of CVE. Patients in the CVE group had higher RDW and Hcy, as compared to the patients in the no CVE group. Multiple Cox regression analysis demonstrated that both RDW (HR = 1.24, 95% CI =1.02–1.56, P = 0.002) and Hcy (HR = 1.37, 95% CI = 1.02–1.80, P < 0.001) resulted significantly related to the CVE. Subsequent analysis found that patients with high RDW had higher Hcy levels as compared with those with low RDW (P = 0.007). Although Pearson's correlation suggested that RDW was positively correlated with Hcy (r = 0.122, P = 0.028), no significant correlation was observed between RDW and Hcy (β = 0.15, p = 0.126) after adjusted for a series of potential confounders using multiple linear regression analysis. In conclusion, RDW is not correlated with Hcy in patients with EH. Both RDW and Hcy are independent risk factors for CVE in newly diagnostic EH and have the potential to improve risk stratification.

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Section: Discussionmentioning

confidence: 99%

Red cell distribution width and homocysteine act as independent risk factors for cardiovascular events in newly diagnostic essential hypertension

Gao²,

Wang

et al. 2017

Oncotarget

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“…Although many prognostic models have been developed in HF, most require the use of calculators limiting their use in daily practice. We have developed a simple score—the Larissa Heart Failure Risk Score (LHFRS)—that risk stratifies patients admitted with acute HF (AHF) . The purpose of this study was to examine the prognostic value of LHFRS in ambulatory patients with chronic HF (CHF).…”

Section: Baseline Characteristics Of the Study Population According Tmentioning

confidence: 99%

“…The derivation of LHFRS has been described in detail . Variables included are hypertension history, myocardial infarction history, and red cell distribution width (RDW) at admission.…”

Section: Baseline Characteristics Of the Study Population According Tmentioning

confidence: 99%

Larissa Heart Failure Risk Score: a proposed simple score for risk stratification in chronic heart failure

Xanthopoulos

Tryposkiadis²,

Giamouzis

et al. 2017

European J of Heart Fail

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“…For the moment it remains unclear whether the genderspecific relevance of RDW is related only to short-term prediction, or whether gender really plays a role. However, RDW is a component of another non-gender-specific risk score developed for prediction of 1-year all-cause mortality and rehospitalization after AHF related hospitalization [2]. Of note, in the latter study B-type natriuretic peptide is not related with the combined endpoint while, in contrast, RDW is so strongly related that it is entered into the risk score [2].…”

mentioning

confidence: 99%

“…Delay of discharge or more intensive post-discharge surveillance may improve the prognosis of AHF patients at high short-term risk of readmission or death, but this requires risk stratification of the individual patient already during the hospitalization. Most important, prediction should be easily applicable and adequate to make risk stratification of this high-risk population worthwhile [1,2].…”

mentioning

confidence: 99%

Red cell distribution width and prognosis in acute heart failure: ready for prime time!

et al. 2018

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A simple score for early risk stratification in acute heart failure

Cited by 22 publications

References 64 publications

Red cell distribution width and homocysteine act as independent risk factors for cardiovascular events in newly diagnostic essential hypertension

Red cell distribution width and homocysteine act as independent risk factors for cardiovascular events in newly diagnostic essential hypertension

Larissa Heart Failure Risk Score: a proposed simple score for risk stratification in chronic heart failure

Red cell distribution width and prognosis in acute heart failure: ready for prime time!

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