A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats

Edwards, P.M.; Parker, V. H.

doi:10.1016/0041-008x(77)90083-7

Cited by 138 publications

(44 citation statements)

References 4 publications

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“…A study 12 was demonstrated that primary chick embryonic midbrain cell cultures exposed to 0.01-10 µM 1,3-DCP and 5-10 mM 1,3-DCA for 48-96 h exhibited that no differences in effects on differentiation were observed in mesencephalon cell cultures with 1,3-DCP and its metabolite 1,3-DCA. Also, our data obtained from PC12 and N18D3 cell cultures at relatively low concentrations (0.1-100 µM) of 1,3-DCP showed no evidence for neurotoxicity, i.e.…”

Section: Discussionmentioning

confidence: 99%

Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats

Song¹,

Kim²,

Park³

et al. 2004

J Toxicol Pathol

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1,3-dichoro-1,2-propanediol (1,3-DCP) is a contaminant of acid-hydrolyzed vegetable protein and a chlorinated compound used in the fabrication of industrial products such as hard resins, celluloid or paints. Several reports have suggested that chronic exposure to 1,3-DCP could produce neurotoxicity in vitro or in neurobehavioral aspects of experimental animals. The present study further explored the in vitro neurotoxic effects of 0.1-100 µM 1,3-DCP on PC12 and N18D3 cell lines. In addition, to investigate the effects of repeated ingestions of 1,3-DCP on neurobehavioral impairments parameters in rats, locomotor activity and landing foot splay tests were preformed, following the treatment of 1,3-DCP at doses of 10, 20, and 30 mg/kg/day for 11 weeks. We demonstrated that no significant neurotoxic effects in vitro and in neurobehavior were observed in the 1,3-DCP-treated rats compared to saline-treated control rats, whereas, acrylamide, used as a positive control, induced significant increases of all neurobehavioral deficit parameters in both male and female rats. On the other hand, body weight gain was significantly decreased in high dose 1,3-DCP-treated male rats as well as in acrylamide-treated rats. Taken together, these results suggest that 1,3-DCP does not produce in vitro neurotoxicity and the neuromotor deficits, at the dose levels of this study. (J Toxicol Pathol 2004; 17: 37-41)

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Section: Discussionmentioning

confidence: 99%

Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats

Song¹,

Kim²,

Park³

et al. 2004

J Toxicol Pathol

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“…An increase in splay is a signature effect produced by acrylamide using dosing schedules that produce a central/peripheral distal axonopathy with accumulations of neurofilaments (3). However, the test has no obvious correlate in human or veterinary neurology, and there is no obvious neurologic rationale for measuring the hind limb splay as a measure of the functional competence of a rat falling through space.…”

Section: Sensory Examinationmentioning

confidence: 99%

ECOs, FOBs, and UFOs: Making Sense of Observational Data

Ross

2000

Toxicol Pathol

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“…In brief, observations take place in the home cage and an open field arena, during which time the subject's movements, physical appearance, and reactions to various stimuli are evaluated. Often also included are manipulations including grip strength (Meyer et al 1979) and landing foot splay (Edwards and Parker 1977). An advantage to this type of screening is that a single animal may be repeatedly assessed to determine the onset, progression, duration, and reversibility of a neurotoxic injury.…”

Section: Screening Batteriesmentioning

confidence: 99%

Functional Assays for Neurotoxicity Testing

Moser

2010

Toxicol Pathol

135

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Neurobehavioral and pathological evaluations of the nervous system are complementary components of basic research and toxicity testing of pharmaceutical and environmental chemicals. While neuropathological assessments provide insight as to cellular changes in neurons, behavioral and physiological methods evaluate the functional consequences of disruption of neuronal communications. The underlying causes of certain behavioral alterations may be understood, but many do not have known direct associations with specific brain pathologies. In some cases, however, rapidly expanding mouse models (transgenic, knock-out) are providing considerable information on behavioral phenotypes of altered pathology. Behavior represents the integrated sum of activities mediated by the nervous system, and functional tests used for neurotoxicity testing tap different behavioral repertoires. These tests have an advantage over pathologic measures in that they permit repeated evaluation of a single animal over time to determine the onset, progression, duration, and reversibility of a neurotoxic injury. Functional assays range from a screening-level battery of tests to refined procedures to tap specific forms of learning and/or memory. This article reviews common procedures for behavioral toxicity testing and provides examples of chemical-specific neurobehavioral-pathological correlations in order to inform interpretation and integration of neuropathological and behavioral outcomes.

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A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats

Cited by 138 publications

References 4 publications

Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats

Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats

ECOs, FOBs, and UFOs: Making Sense of Observational Data

Functional Assays for Neurotoxicity Testing

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