A simple sonochemical assisted synthesis of nanocomposite (ZnO/MWCNTs) for electrochemical sensing of Epinephrine in human serum and pharmaceutical formulation

Shaikshavali, P.; Reddy, T. Madhusudana; Gopal, T. Venu; Venkataprasad, G.; Kotakadi, Venkata Subbaiah; Palakollu, Venkata Narayana; Karpoormath, Rajshekhar

doi:10.1016/j.colsurfa.2019.124038

Cited by 71 publications

(36 citation statements)

References 60 publications

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“…In impedance spectra, the smaller the capacitance arc, the stronger the charge transfer capability, and also the better the decomposition behavior. [ 44,45 ] As seen, Mg–14Zn–Zr alloy exhibits the minimum capacitance arc, indicating the optimal decomposition ability. Meanwhile, capacitive arc size reduces with the increase of Zn content, suggesting gradually improved decomposition ability, which also coincides with polarization results in Figure 9.…”

Section: Resultsmentioning

confidence: 90%

Microstructures and electrochemical behaviors of as‐cast magnesium alloys with enhanced compressive strengths and corrosion decomposition

Tian

et al. 2020

Materials & Corrosion

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Rapidly disintegrating alloys with enhanced compressive strengths and corrosion rates are prepared for fracturing parts in petroleum extraction. Extrusion casting is used to prepare Mg-xZn-Zr alloys by adjusting zinc content. Mechanical and electrochemical behaviors are investigated to evaluate the practicability as decomposable materials. Superficial topographies, compositions, phases, and distributions are also characterized to determine the dissociative mechanism. The results make clear that matrixes and secondary structures with reticulate shapes arise on surfaces. The material also possesses enhanced compressive strength to guarantee stabilization and pressureholding ability among decomposition. Concurrently, with the increase of zinc content and decomposition time, galvanic corrosion aggravates resulting in gradually reduced corrosion potentials and accelerated decomposition rates. Rapid material dissolution mainly attributes to anode corrosion of matrixes, peeling of microparticles, and inferior tolerance of corrosive products to dissolution. Such work highlights potential applications of fracturing materials for ensuring rapid decomposition and guaranteeing stable stress tolerance.

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Section: Resultsmentioning

confidence: 90%

Microstructures and electrochemical behaviors of as‐cast magnesium alloys with enhanced compressive strengths and corrosion decomposition

Tian

et al. 2020

Materials & Corrosion

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“…All the modified GCE layers revealed a linear pattern related to diffusion behaviour as displayed in Figure 6. with low R ct values [23]. IL‐ZnONPs‐f‐MWCNTs‐GCE showed insignificant transfer resistance (R ct ) as compared to the control electrodes f‐MWCNTs‐GCE and ZnONPs‐f‐MWCNTs‐GCE (Table 2).…”

Section: Resultsmentioning

confidence: 98%

“…The novelty of f-MWCNTs based electrochemical sensors are sought due to the exclusive geometrical, electronic and automatic properties of MWCNTs [21,22]. The f-MWCNTs and metal oxide nanoparticles are good electro active species for the redox reactions [23]. However, the bare glassy carbon electrode (GCE) causes strong adsorption of redox products which limits its applicability for routine analysis of AMY and may cause reproducibility problems.…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid and f‐MWCNTs Fabricated Glassy Carbon Electrode for Determination of Amygdalin in Apple Seeds

Chokkareddy

2020

Electroanalysis

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This work proposes a novel electrochemical sensor based on functionalised multiwalled carbon nanotubes (f-MWCNTs), zinc oxide nanoparticles (ZnONPs), and (methyltrioctylammonium chloride ionic liquid (IL)) fabricated glassy carbon electrode (GCE), for the determination of amygdalin (AMY) in apple seeds. X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), Fourier-transform infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), Thermogravimetric analysis (TGA) as well as electrochemical impedance spectroscopy (EIS) techniques were used to characterize the synthesized ZnONPs and its nanocomposite. EIS and differential Pulse Voltammetry (DPV) was utilized to investigate the electrochemical behavior of AMY on the IL-ZnONPs-f-MWCNTs nanocomposite modified GCE. The linear range response is obtained from 0.012-6 μM for AMY determination under optimized experimental conditions, and the limit of detection (LOD) values were found to be 0.012 μM. The novel method developed was successfully used to determine AMY in spiked apple seed samples with satisfactory results.

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“…The cathodic peak (peak B in Figure 1 b) corresponds to the reduction of epinephrine quinone to EP. Peaks C and D demonstrate the reversible electrochemical reaction of the reduction of adrenochrome to leukoadrenochrome (peak C, Figure 1 b) followed by its regeneration, while sweeping in the anodic direction (peak D, Figure 1 b) [ 34 ]. Since EP produces an electrochemical response by sweeping the E in both directions (anodic and cathodic), two different methods for its detection were developed and validated using SWV.…”

Section: Resultsmentioning

confidence: 99%

An Advanced Statistical Approach Using Weighted Linear Regression in Electroanalytical Method Development for Epinephrine, Uric Acid and Ascorbic Acid Determination

Majer

Mastnak

Finšgar

2020

Sensors

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In this study, the use of weighted linear regression in the development of electrochemical methods for the determination of epinephrine (EP), ascorbic acid (AA), and uric acid (UA) is presented. The measurements were performed using a glassy carbon electrode and square-wave voltammetry (SWV). All electroanalytical methods were validated by determination of the limit of detection, limit of quantification, linear concentration range, accuracy, and precision. The normal distribution of all data sets was checked using the quantile-quantile plot and Kolmogorov-Smirnov statistical tests. The heteroscedasticity of the data was tested using Hartley’s test, Bartlett’s test, Cochran’s C test, and the analysis of residuals. The heteroscedastic behavior was observed with all analytes, justifying the use of weighted linear regression. Six different weighting factors were tested, and the best weighted model was determined using relative percentage error. Such statistical approach improved the regression models by giving greater weight on the values with the smallest error and vice versa. Consequently, accuracy of the analytical results (especially in the lower concentration range) was improved. All methods were successfully used for the determination of these analytes in real samples: EP in an epinephrine auto-injector, AA in a dietary supplement, and UA in human urine. The accuracy and precision of real sample analysis using best weighted model gave satisfactory results with recoveries between 95.21–113.23% and relative standard deviations between 0.85–7.98%. The SWV measurement takes about 40 s, which makes the presented methods for the determination of EP, AA, and UA a promising alternative to chromatographic techniques in terms of speed, analysis, and equipment costs, as the analysis is performed without organic solvents.

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A simple sonochemical assisted synthesis of nanocomposite (ZnO/MWCNTs) for electrochemical sensing of Epinephrine in human serum and pharmaceutical formulation

Cited by 71 publications

References 60 publications

Microstructures and electrochemical behaviors of as‐cast magnesium alloys with enhanced compressive strengths and corrosion decomposition

Microstructures and electrochemical behaviors of as‐cast magnesium alloys with enhanced compressive strengths and corrosion decomposition

Ionic Liquid and f‐MWCNTs Fabricated Glassy Carbon Electrode for Determination of Amygdalin in Apple Seeds

An Advanced Statistical Approach Using Weighted Linear Regression in Electroanalytical Method Development for Epinephrine, Uric Acid and Ascorbic Acid Determination

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