A Simple Synthesis ofD-Myo-Inositol 4-Phosphate andD-Myo-Inositol 6-Phosphate

Amides of Trivalent Phosphorus Acids as Phosphorylating Reagents for Proton-Donating Nucleophiles

“…Filigree experiments on targeted introduction of protective groups into the cyclitol system followed by phosphorylation, giving rise to myoinositols phosphites containing up to five phosphorus atoms, have been described in a number of studies. Phosphorus amide 31 , , dibenzyl N , N -dialkylphosphoramidites, − and o -xylylenyl N , N -dialkylphosphoramidites , were recommended as phosphorylating reagents for this purpose. The last-mentioned reagents are the most convenient.…”

Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates

“…To resolve the regioselectivity issue, we employed the Sn (IV) catalysts because Sn (IV) catalysts are known to form the complex with cis -diols in a regioselective manner and increase their reactivity . After systematic exploratory experiments (varying the equivalents of BDMDAP, temperature, solvents, and activators; SI, Table 2), we found that 1 equiv of BDMDAP in NMP as solvent at 80 °C afforded 75% conversion to cyclophosphate product 4 (SI, Table 2, entry 19).…”